recent publications

• academic article

  • Seo, J. W., Ma, M., Kwong, T., Ju, J., Lim, S. K., Jiang, H., Lohman, J. R., Yang, C., Cleveland, J., Zazopoulos, E., Farnet, C. M., Shen, B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues Biochemistry  2014 53:7854-7865  DOI:10.1021/bi501396v  PMID:25405956  PMCID:PMC4270375
  • Ma, M., Kwong, T., Lim, S. K., Ju, J. H., Lohman, J. R., Shen, B. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity Journal of the American Chemical Society  2013 135:2489-2492  DOI:10.1021/ja4002635  PMID:23394593  PMCID:PMC3582021
  • Lim, S. K., Park, M. J., Lim, J. C., Kim, J. C., Han, H. J., Kim, G. Y., Cravatt, B. F., Woo, C. H., Ma, S. J., Yoon, K. C., Park, S. H. Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells Journal of Cellular Physiology  2012 227:569-577  DOI:10.1002/jcp.22756  PMID:21442624
  • Lim, S. K., Ju, J. H., Zazopoulos, E., Jiang, H., Seo, J. W., Chen, Y. H., Feng, Z. Y., Rajski, S. R., Farnet, C. M., Shen, B. Iso-migrastatin, migrastatin, and dorrigocin production in streptomyces platensis nrrl 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type i polyketide synthase Journal of Biological Chemistry  2009 284:29746-29756  DOI:10.1074/jbc.M109.046805  PMID:19726666  PMCID:PMC2785606
  • Ju, J. H., Rajski, S. R., Lim, S. K., Seo, J. W., Peters, N. R., Hoffmann, F. M., Shen, B. Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration Journal of the American Chemical Society  2009 131:1370-1371  DOI:10.1021/ja808462p  PMID:19132897  PMCID:PMC2651819
  • Ju, J. H., Rajski, S. R., Lim, S. K., Seo, J. W., Peters, N. R., Hoffmann, F. M., Shen, B. Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency Bioorganic & Medicinal Chemistry Letters  2008 18:5951-5954  DOI:10.1016/j.bmcl.2008.07.072  PMID:18684620  PMCID:PMC2585373
  • Ju, J., Seo, H. W., Her, Y., Lim, S. K., Shen, B. New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in streptomyces amphibiosporus Organic Letters  2007 9:5183-5186  DOI:10.1021/ol702249g  PMID:17997563
  • Ju, J. H., Lim, S. K., Jiang, H., Seo, J. W., Her, Y., Shen, B. Thermolysis of isomigrastatin and its congeners via 3,3 -sigmatropic rearrangement: A new route to the synthesis of migrastatin and its analogues Organic Letters  2006 8:5865-5868  DOI:10.1021/01062470p  PMID:17134292
  • Ju, J. H., Lim, S. K., Jiang, H., Seo, J. W., Shen, B. Iso-migrastatin congeners from streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and nk30424 scaffolds Journal of the American Chemical Society  2005 127:11930-11931  DOI:10.1021/ja053118u  PMID:16117518
  • Ju, J. H., Lim, S. K., Jiang, H., Shen, B. Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin Journal of the American Chemical Society  2005 127:1622-1623  DOI:10.1021/ja043808i  PMID:15700980