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Differential regulation of antiviral T-cell immunity results in stable CD8(+) but declining CD4(+) T-cell memory

Academic Article
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Overview

authors

  • Homann, D.
  • Teyton, Luc
  • Oldstone, Michael

publication date

  • August 2001

journal

  • Nature Medicine  Journal

abstract

  • Emerging evidence indicates that CD8+ and CD4+ T-cell immunity is differentially regulated. Here we have delineated differences and commonalities among antiviral T-cell responses by enumeration and functional profiling of eight specific CD8+ and CD4+ T-cell populations during primary, memory and recall responses. A high degree of coordinate regulation among all specific T-cell populations stood out against an approximately 20-fold lower peak expansion and prolonged contraction phase of specific CD4+ T-cell populations. Surprisingly, although CD8+ T-cell memory was stably maintained for life, levels of specific CD4+ memory T cells gradually declined. However, this decay, which seemed to result from less efficient rescue from apoptosis, did not affect functionality of surviving virus-specific CD4+ T cells. Our results indicate that CD4+ T-cell memory might become limiting under physiological conditions and that conditions precipitating CD4+ T-cell loss might compromise protective immunity even in the presence of unimpaired CD8+ T-cell responses.

subject areas

  • Amino Acid Sequence
  • Animals
  • Apoptosis
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Immunologic Memory
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
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Identity

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/90950

PubMed ID

  • 11479623
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Additional Document Info

start page

  • 913

end page

  • 919

volume

  • 7

issue

  • 8

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