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To kill or to cure: Options in host defense against viral infection

Academic Article
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Overview

authors

  • Guidotti, Luca
  • Chisari, Francis

publication date

  • August 1996

journal

  • Current Opinion in Immunology  Journal

abstract

  • It is generally thought that viral clearance is mediated primarily by antigen-specific T cell responses that destroy infected cells. This assumption may not be true for all viruses. Recent studies using a transgenic mouse model of hepatitis B virus infection have shown that adoptively transferred, virus-specific cytotoxic T cells can abolish hepatitis B virus gene expression and replication in the liver without killing the hepatocytes. This effect is mediated by interferon-gamma and tumor necrosis factor-alpha, which are secreted by the cytotoxic T lymphocytes following antigen recognition. Similar noncytopathic cytokine-dependent 'curative' processes also occur in this model during an unrelated infection of the liver. Intracellular viral inactivation mechanisms such as these could greatly amplify the protective effects of the immune response. Research has also been carried out to clarify the relevance of curative versus destructive mechanisms of viral clearance in other models of viral infection.

subject areas

  • Animals
  • Hepatitis B
  • Virus Diseases
  • Virus Latency
  • Viruses
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Identity

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/s0952-7915(96)80034-3

PubMed ID

  • 8794011
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Additional Document Info

start page

  • 478

end page

  • 483

volume

  • 8

issue

  • 4

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