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Functional STAT 1 and 3 signaling by the leptin receptor (OB-R): reduced expression of the rat fatty leptin receptor in transfected cells

Academic Article
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Overview

authors

  • Rosenblum, C. I.
  • Tota, M.
  • Cully, D.
  • Smith, T.
  • Collum, R.
  • Qureshi, S.
  • Hess, J. F.
  • Phillips, M. S.
  • Hey, P. J.
  • Vongs, A.
  • Fong, T. M.
  • Xu, L.
  • Chen, H. Y.
  • Smith, Roy
  • Schindler, C.
  • VanderPloeg, L. H. T.

publication date

  • November 1996

journal

  • Endocrinology  Journal

abstract

  • The leptin receptor (OB-R) bears homology to members of the class I cytokine receptor family. We demonstrate that leptin binding to OB-R stimulates formation of STAT-1 and STAT-3 complexes, thereby defining transcriptional motifs for genes that are under leptin control. Transfected fa OB-R bound leptin with equal affinity to that of wild type OB-R. fa OB-R abundance was about 7 fold reduced compared to control cells. Surprisingly, the low level of fa OB-R is fully capable of activating the STAT signal transduction pathway. We discuss plausible explanations for the obese phenotype in Zucker fatty rats.

subject areas

  • Animals
  • Base Sequence
  • COS Cells
  • Carrier Proteins
  • Cell Line
  • DNA Probes
  • DNA-Binding Proteins
  • Hypothalamus
  • Kinetics
  • Leptin
  • Mice
  • Obesity
  • Oligodeoxyribonucleotides
  • Polymerase Chain Reaction
  • Proteins
  • Rats
  • Rats, Zucker
  • Receptors, Cell Surface
  • Receptors, Leptin
  • Recombinant Proteins
  • STAT1 Transcription Factor
  • STAT3 Transcription Factor
  • Signal Transduction
  • Trans-Activators
  • Transfection
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Identity

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/en.137.11.5178

PubMed ID

  • 8895396
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Additional Document Info

start page

  • 5178

end page

  • 5181

volume

  • 137

issue

  • 11

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