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Protective effects of heme oxygenase-1 against mpp(+)-induced cytotoxicity in pc-12 cells

Academic Article
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Overview

authors

  • Bae, J. W.
  • Kim, M. J.
  • Jang, Choon-Gon
  • Lee, S. Y.

publication date

  • June 2010

journal

  • Neurological Sciences  Journal

abstract

  • Heme oxygenase-1 (HO-1) catalyses the rate-limiting step of heme degradation to biliverdin, which is in turn reduced to bilirubin, CO and free iron. HO-1 can be induced by several harmful stimuli including oxidative stress, and it has a protective role against the cytotoxicity in different cells. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinium (MPP(+)) is a neurotoxic substance that induces the degeneration of dopaminergic neurons. This study examined whether HO-1 can be induced by MPP(+) and whether HO-1 has a protective role against the MPP(+)-induced cytotoxicity in PC-12 cells. MPP(+) triggered a relatively rapid induction of HO-1. The MPP(+)-induced cytotoxicity and reactive oxygen species (ROS) production markedly increased by HO-1 inhibitor, zinc protoporphyrin-IX (ZnPP-IX). The increase of ROS production by ZnPP-IX was completely abrogated by either two products of HO (biliverdin or bilirubin) while the increase of cytotoxicity by ZnPP-IX was attenuated partially. These suggest that HO-1 expression might have some cytoprotective effect against MPP(+)-induced cytotoxicity.

subject areas

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Bilirubin
  • Biliverdine
  • Cell Death
  • Cell Membrane
  • Cell Survival
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors
  • Heme Oxygenase (Decyclizing)
  • MPTP Poisoning
  • Neurons
  • Neurotoxins
  • PC12 Cells
  • Protoporphyrins
  • Rats
  • Reactive Oxygen Species
  • Time Factors
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Research

keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinium (MPP+)
  • Cytotoxicity
  • Heme oxygenase-1 (HO-1)
  • PC-12 cell
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Identity

International Standard Serial Number (ISSN)

  • 1590-1874

Digital Object Identifier (DOI)

  • 10.1007/s10072-010-0216-6

PubMed ID

  • 20127499
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Additional Document Info

start page

  • 307

end page

  • 313

volume

  • 31

issue

  • 3

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