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Emerging medicinal roles for lysophospholipid signaling

Academic Article
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Overview

authors

  • Gardell, S. E.
  • Dubin, Adrienne
  • Chun, Jerold

publication date

  • February 2006

journal

  • Trends in Molecular Medicine  Journal

abstract

  • The two lysophospholipids (LPs) lysophosphatidic acid and sphingosine 1-phosphate (S1P) regulate diverse biological processes. Over the past decade, it has become clear that medically relevant LP activities are mediated by specific G protein-coupled receptors, implicating them in the etiology of a growing number of disorders. A new class of LP agonists shows promise for drug therapy: the experimental drug FTY720 is phosphorylated in vivo to produce a potent S1P receptor agonist (FTY720-P) and is currently in Phase III clinical trials for kidney transplantation and Phase II for multiple sclerosis. Recent genetic and pharmacological studies on LP signaling in animal disease models have identified new areas in which interventions in LP signaling might provide novel therapeutic approaches for the treatment of human diseases.

subject areas

  • Animals
  • Autoimmune Diseases
  • Cardiovascular Diseases
  • Humans
  • Lysophospholipids
  • Neoplasms
  • Obesity
  • Phosphorylation
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Receptors, Lysosphingolipid
  • Signal Transduction
  • Sphingosine
  • Transplantation Immunology
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Identity

International Standard Serial Number (ISSN)

  • 1471-4914

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2005.12.001

PubMed ID

  • 16406843
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Additional Document Info

start page

  • 65

end page

  • 75

volume

  • 12

issue

  • 2

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