Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Trimbuch, T.
  • Beed, P.
  • Vogt, J.
  • Schuchmann, S.
  • Maier, N.
  • Kintscher, M.
  • Breustedt, J.
  • Schuelke, M.
  • Streu, N.
  • Kieselmann, O.
  • Brunk, I.
  • Laube, G.
  • Strauss, U.
  • Battefeld, A.
  • Wende, H.
  • Birchmeier, C.
  • Wiese, S.
  • Sendtner, M.
  • Kawabe, H.
  • Kishimoto-Suga, M.
  • Brose, N.
  • Baumgart, J.
  • Geist, B.
  • Aoki, J.
  • Savaskan, N. E.
  • Brauer, A. U.
  • Chun, Jerold
  • Ninnemann, O.
  • Schmitz, D.
  • Nitsch, R.

publication date

  • 2009

journal

  • Cell  Journal

abstract

  • Plasticity related gene-1 (PRG-1) is a brain-specific membrane protein related to lipid phosphate phosphatases, which acts in the hippocampus specifically at the excitatory synapse terminating on glutamatergic neurons. Deletion of prg-1 in mice leads to epileptic seizures and augmentation of EPSCs, but not IPSCs. In utero electroporation of PRG-1 into deficient animals revealed that PRG-1 modulates excitation at the synaptic junction. Mutation of the extracellular domain of PRG-1 crucial for its interaction with lysophosphatidic acid (LPA) abolished the ability to prevent hyperexcitability. As LPA application in vitro induced hyperexcitability in wild-type but not in LPA(2) receptor-deficient animals, and uptake of phospholipids is reduced in PRG-1-deficient neurons, we assessed PRG-1/LPA(2) receptor-deficient animals, and found that the pathophysiology observed in the PRG-1-deficient mice was fully reverted. Thus, we propose PRG-1 as an important player in the modulatory control of hippocampal excitability dependent on presynaptic LPA(2) receptor signaling.

subject areas

  • Animals
  • Electroencephalography
  • Hippocampus
  • Lysophospholipids
  • Mice
  • Mice, Knockout
  • Proteoglycans
  • Receptors, AMPA
  • Receptors, Lysophosphatidic Acid
  • Signal Transduction
  • Synapses
  • Vesicular Transport Proteins
scroll to property group menus

Identity

PubMed Central ID

  • PMC3716297

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2009.06.050

PubMed ID

  • 19766573
scroll to property group menus

Additional Document Info

start page

  • 1222

end page

  • 1235

volume

  • 138

issue

  • 6

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support