Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Ng-hydroxyguanidines from primary amines

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Martin, N. I.
  • Woodward, J. J.
  • Marletta, Michael

publication date

  • August 2006

journal

  • Organic Letters  Journal

abstract

  • A concise and general method for the preparation of N(G)-hydroxyguanidines from primary amines is reported. Using available and readily prepared materials, primary amines are converted to protected N(G)-hydroxyguanidines in a one-pot procedure followed by deprotection under nonreducing conditions. The method has been successfully applied to a number of examples including a high-yielding preparation of N(G)-hydroxy-L-arginine, the intermediate in the enzymatic conversion of L-arginine to nitric oxide and L-citrulline by nitric oxide synthase.

subject areas

  • Amines
  • Guanidines
  • Molecular Structure
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol061454p

PubMed ID

  • 16928067
scroll to property group menus

Additional Document Info

start page

  • 4035

end page

  • 4038

volume

  • 8

issue

  • 18

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support