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Arginine vasopressin and a vasopressin antagonist peptide - opposite effects on extinction of active-avoidance in rats

Academic Article
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Overview

authors

  • Koob, George
  • Lemoal, M.
  • Gaffori, O.
  • Manning, M.
  • Sawyer, W. H.
  • Rivier, J.
  • Bloom, Floyd

publication date

  • 1981

journal

  • Regulatory Peptides  Journal

abstract

  • Systemic injection or arginine vasopressin (AVP) (1 micrograms/rat) significantly prolonged extinction of a pole-jump, active avoidance response in rats; lateral ventricular injection of 1000-fold less AVP (1 ng/rat) produced similar results. A new AVP analogue, [1-deaminopenicillamine-2-(O-methyl)tyrosine]arginine vasopressin (dPTyr-(Me)AVP), is known to antagonize behavioral and vascular effects of exogenous AVP at molar ratios of 5 : 1. At a dose of 100 micrograms/rat (subcutaneously) dPTyr-(Me)AVP produces, by itself, a behavioral effect opposite to that of exogenous AVP, namely a facilitation of extinction. Injections of dPTyr-(Me)AVP into the lateral ventricle were ineffective except at a dose of 10 micrograms/rat. These results confirm previous reports of the effect of vasopressin on delaying extinction of avoidance behavior, but suggest a site of action distant from the lateral ventricle.

subject areas

  • Animals
  • Arginine Vasopressin
  • Avoidance Learning
  • Dose-Response Relationship, Drug
  • Extinction, Psychological
  • Injections, Intraventricular
  • Kinetics
  • Male
  • Rats
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Identity

International Standard Serial Number (ISSN)

  • 0167-0115

Digital Object Identifier (DOI)

  • 10.1016/0167-0115(81)90009-4

PubMed ID

  • 7255768
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Additional Document Info

start page

  • 153

end page

  • 163

volume

  • 2

issue

  • 3

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