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Sequence-selective DNA recognition: natural products and nature's lessons

Academic Article
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Overview

related to degree

  • Tse, Winston, Ph.D. in Chemistry, Scripps Research 1998 - 2003

authors

  • Tse, Winston
  • Boger, Dale

publication date

  • December 2004

journal

  • Chemistry & Biology  Journal

abstract

  • Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular selectivity, and to provide a rich source of new drugs. These attributes arise in compact structures of complex integrated function.

subject areas

  • Animals
  • Antineoplastic Agents
  • DNA
  • Humans
  • Models, Molecular
  • Molecular Conformation
  • Protein Binding
  • Stereoisomerism
  • Structure-Activity Relationship
  • Substrate Specificity
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Identity

International Standard Serial Number (ISSN)

  • 1074-5521

Digital Object Identifier (DOI)

  • 10.1016/j.chembiol.2003.08.012

PubMed ID

  • 15610844
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Additional Document Info

start page

  • 1607

end page

  • 1617

volume

  • 11

issue

  • 12

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