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Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection

Academic Article
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Overview

authors

  • Rehermann, B.
  • Lau, D.
  • Hoofnagle, J. H.
  • Chisari, Francis

publication date

  • April 1996

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Clearance of the hepatitis B virus (HBV) during acute hepatitis is associated with a strong, polyclonal, multispecific cytotoxic T lymphocyte (CTL) response to the viral envelope, nucleocapsid and polymerase proteins that persists for decades after clinical recovery. In contrast, chronically infected patients usually fail to mount a strong CTL response to this virus. In this study we demonstrate that chronically infected patients who experience a spontaneous or interferon-induced remission develop a CTL response to HBV that is similar in strength and specificity to patients who have recovered from acute hepatitis. The results suggest that specific immunotherapeutic enhancement of the CTL response to HBV should be possible in chronically infected patients, and that it could lead to viral clearance in these individuals with resolution of chronic liver disease.

subject areas

  • Acute Disease
  • Adult
  • Aged
  • Alanine Transaminase
  • Base Sequence
  • CD8-Positive T-Lymphocytes
  • Case-Control Studies
  • DNA Primers
  • DNA, Viral
  • Female
  • Hepatitis B
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
  • Hepatitis B virus
  • Hepatitis, Chronic
  • Humans
  • In Vitro Techniques
  • Interferon Type I
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Recombinant Proteins
  • T-Lymphocytes, Cytotoxic
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Research

keywords

  • CTL
  • HBV
  • HLA-A2
  • interferon
  • limiting dilution analysis
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Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci118592

PubMed ID

  • 8601631
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Additional Document Info

start page

  • 1655

end page

  • 1665

volume

  • 97

issue

  • 7

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