PCNA/cyclin: a lupus antigen connected with DNA replication

Academic Article

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Overview

authors

• Tan, Eng
• Ogata, K.
• Takasaki, Y.

publication date

• June 1987

journal

• Journal of Rheumatology  Journal

abstract

• Molecular analysis of the proliferating cell nuclear antigen (PCNA) has the 2-fold goal of utilizing the unique tools provided by autoimmune sera to study the function of this important intracellular molecule and to provide insights into the etiology of autoimmune disease. PCNA is expressed in the nucleus immediately preceding S phase and, during S phase is colocalized with sites of active DNA synthesis. There is currently available not only a battery of human sera which can be rendered monospecific for PCNA, but also monoclonal antibodies and rabbit antipeptide antibodies. With these reagents, it might be possible to isolate cDNA clones from cDNA expression libraries.

subject areas

• Antibodies, Monoclonal
• Antibody Specificity
• Cell Nucleolus
• DNA Replication
• Humans
• Interphase
• Lupus Erythematosus, Systemic
• Lymphocyte Activation
• Nucleoproteins
• Proliferating Cell Nuclear Antigen

Identity

International Standard Serial Number (ISSN)

• 0315-162X

PubMed ID

• 2886661

Additional Document Info

start page

• 89

end page

• 96

volume

• 14