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Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization

Academic Article
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Overview

authors

  • Izzo, E.
  • Martin-Fardon, Remi
  • Koob, George
  • Weiss, Friedbert
  • Sanna, Pietro

publication date

  • December 2002

journal

  • Nature Neuroscience  Journal

abstract

  • Drug addiction has been linked to protracted functional changes in neural circuits involved in motivation that can lead to drug dependence, craving and relapse. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signal transduction pathway in long-lasting behavioral sensitization to cocaine in rats, an animal model of the long-lasting functional changes induced by repeated drug use. Our results show that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine.

subject areas

  • Animals
  • Behavior, Animal
  • Brain
  • Chromones
  • Cocaine
  • Cocaine-Related Disorders
  • Disease Models, Animal
  • Enzyme Inhibitors
  • Male
  • Morpholines
  • Motor Activity
  • Neuronal Plasticity
  • Neurons
  • Phosphatidylinositol 3-Kinases
  • Rats
  • Rats, Wistar
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn977

PubMed ID

  • 12436114
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Additional Document Info

start page

  • 1263

end page

  • 1264

volume

  • 5

issue

  • 12

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