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Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

Academic Article
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Overview

authors

  • Lotz, Martin
  • Guerne, P. A.

publication date

  • February 1991

journal

  • Journal of Biological Chemistry  Journal

abstract

  • This study examines the role of interleukin-6 (IL-6) in connective tissue metabolism. Effects of different preparations of IL-6 on production of collagenase and tissue inhibitor of metalloproteinases-1/erythroid potentiating activity production are studied in human fibroblasts, synoviocytes, and articular chondrocytes. In contrast to interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha), IL-6 does not stimulate the production of collagenase, nor does it modulate the stimulatory effects of IL-1 beta and TNF alpha on the production of this proteinase. Furthermore, IL-6 has no detectable effect on prostaglandin E2 production, an additional proinflammatory response induced by IL-1 beta and TNF alpha. IL-6, however, is identified as a potent inducer of de novo synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity in all types of connective tissue cells examined. These results define new biological activities of IL-6 and provide further insight into the regulation of connective tissues by cytokines.

subject areas

  • Cartilage, Articular
  • Dinoprostone
  • Fibroblasts
  • Glycoproteins
  • Humans
  • Interleukin-1
  • Interleukin-6
  • Lymphokines
  • Metalloendopeptidases
  • Microbial Collagenase
  • Synovial Fluid
  • Tissue Inhibitor of Metalloproteinases
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

PubMed ID

  • 1846608
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Additional Document Info

start page

  • 2017

end page

  • 2020

volume

  • 266

issue

  • 4

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