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Reduced nnos expression induced by repeated nicotine treatment in mu-opioid receptor knockout mice

Academic Article
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Overview

authors

  • Yoo, J. H.
  • Cho, J. H.
  • Lee, S. Y.
  • Loh, H. H.
  • Ho, I. K.
  • Jang, Choon-Gon

publication date

  • May 2005

journal

  • Neuroscience Letters  Journal

abstract

  • To determine whether neuronal nitric oxide synthase (nNOS) is involved in nicotine-induced behavioral sensitization in mu-opioid receptor knockout mice we adopted an immunohistochemical approach. Our results confirm that repeated nicotine administration increased locomotor activity in wild-type mice, but failed to increase locomotor activity in mu-opioid receptor knockout mice, thus suggesting that the mu-opioid receptor is involved in behavioral sensitization. Higher numbers of nNOS-positive cells were observed in the striatum of wild-type mice repeatedly treated with nicotine than in saline-treated wild-type mice. However, mu-opioid receptor knockout mice showed significantly lower nicotine-induced nNOS expression in the striatum versus wild-type mice. No differences were found in the hilus of the dentate gyrus between wild-type and mu-opioid receptor knockout mice. These findings demonstrate that the absence of mu-opioid receptors can cause a significant reduction in the expression of nNOS in the striatum, as induced by repeated nicotine treatment.

subject areas

  • Analysis of Variance
  • Animals
  • Behavior, Animal
  • Brain
  • Cell Culture Techniques
  • Gene Expression Regulation
  • Immunohistochemistry
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nerve Tissue Proteins
  • Nicotine
  • Nicotinic Agonists
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I
  • Receptors, Opioid, mu
  • Time Factors
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Research

keywords

  • immunohistochemistry
  • knockout mice
  • mu-opioid receptors
  • nicotine
  • nnos
  • sensitization
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2005.01.001

PubMed ID

  • 15854753
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Additional Document Info

start page

  • 70

end page

  • 74

volume

  • 380

issue

  • 1-2

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