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Calmodulin regulation of calcium stores in phototransduction of Drosophila

Academic Article
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Overview

authors

  • Arnon, A.
  • Cook, Boaz
  • Montell, C.
  • Selinger, Z.
  • Minke, B.

publication date

  • February 1997

journal

  • Science  Journal

abstract

  • Phototransduction in Drosophila occurs through the ubiquitous phosphoinositide-mediated signal transduction system. Major unresolved questions in this pathway are the identity and role of the internal calcium stores in light excitation and the mechanism underlying regulation of Ca2+ release from internal stores. Treatment of Drosophila photoreceptors with ryanodine and caffeine disrupted the current induced by light, whereas subsequent application of calcium-calmodulin (Ca-CaM) rescued the inactivated photoresponse. In calcium-deprived wild-type Drosophila and in calmodulin-deficient transgenic flies, the current induced by light was disrupted by a specific inhibitor of Ca-CaM. Furthermore, inhibition of Ca-CaM revealed light-induced release of calcium from intracellular stores. It appears that functional ryanodine-sensitive stores are essential for the photoresponse. Moreover, calcium release from these stores appears to be a component of Drosophila phototransduction, and Ca-CaM regulates this process.

subject areas

  • Animals
  • Animals, Genetically Modified
  • Caffeine
  • Calcium
  • Calcium-Transporting ATPases
  • Calmodulin
  • Drosophila
  • Enzyme Inhibitors
  • In Vitro Techniques
  • Light
  • Patch-Clamp Techniques
  • Photoreceptor Cells, Invertebrate
  • Ryanodine
  • Signal Transduction
  • Thapsigargin
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.275.5303.1119

PubMed ID

  • 9027311
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Additional Document Info

start page

  • 1119

end page

  • 1121

volume

  • 275

issue

  • 5303

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