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T cells can use either t cell receptor or cd28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells

Academic Article
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Overview

authors

  • Hwang, I.
  • Huang, Jing-Feng
  • Kishimoto, H.
  • Brunmark, A.
  • Peterson, P. A.
  • Jackson, M. R.
  • Surh, Charles
  • Cai, Z. L.
  • Sprent, Jonathan

publication date

  • 2000

journal

  • Journal of Experimental Medicine  Journal

abstract

  • At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)-peptide-major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule 1 (ICAM-1), respectively, on APCs. Here, we show that during T cell-APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least two receptors on T cells, namely CD28 and TCR molecules. The biological significance of T cell uptake of molecules from APCs is unclear. One possibility is that this process may allow activated T cells to move freely from one APC to another and eventually gain entry into the circulation.

subject areas

  • Animals
  • Antigen-Presenting Cells
  • Antigens, CD
  • Antigens, CD28
  • Antigens, CD80
  • Antigens, CD86
  • Cell Line
  • Dendritic Cells
  • Drosophila
  • Endocytosis
  • Intercellular Adhesion Molecule-1
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Knockout
  • Mice, SCID
  • Mice, Transgenic
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes
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Research

keywords

  • CD28
  • T cell receptor
  • absorption
  • antigen presenting cells
  • internalization
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.191.7.1137

PubMed ID

  • 10748232
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Additional Document Info

start page

  • 1137

end page

  • 1148

volume

  • 191

issue

  • 7

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