recent publications

• academic article

  • Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala Journal of Pharmacology and Experimental Therapeutics  2015 355:206-211  DOI:10.1124/jpet.115.225870  PMID:26350161  PMCID:PMC4613963
  • Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience  2014 17:1751-1758  DOI:10.1038/nn.3872  PMID:25402857  PMCID:PMC4241147
  • Contet, C., Kim, A., Le, D., Iyengar, S. K., Kotzebue, R. W., Yuan, C. J., Kieffer, B. L., Mandyam, C. D. mu-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche Addiction Biology  2014 19:770-780  DOI:10.1111/adb.12040  PMID:23461397  PMCID:PMC3681911
  • Cohen, A., Whitfield, T. W., Kreifeldt, M., Koebel, P., Kieffer, B. L., Contet, C., George, O., Koob, G. F. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization PLoS One  2014 9:e97216  DOI:10.1371/journal.pone.0097216  PMID:24816773  PMCID:PMC4016270
  • Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Kappa-opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites Journal of Pharmacology and Experimental Therapeutics  2013 346:130-137  DOI:10.1124/jpet.112.202903  PMID:23587526  PMCID:PMC3684840
  • Contet, C., Gardon, O., Filliol, D., Becker, J. A. J., Koob, G. F., Kieffer, B. L. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence Addiction Biology  2011 16:615-619  DOI:10.1111/j.1369-1600.2010.00304.x  PMID:21392173  PMCID:PMC3139763
  • Scherrer, G., Imamachi, N., Cao, Y. Q., Contet, C., Mennicken, F., O'Donnell, D., Kieffer, B. L., Basbaum, A. I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain Cell  2009 137:1148-1159  DOI:10.1016/j.cell.2009.04.019  PMID:19524516  PMCID:PMC3683597
  • Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics  2009 328:284-293  DOI:10.1124/jpet.108.140749  PMID:18854491  PMCID:PMC2685907
  • Contet, C., Filliol, D., Matifas, A., Kieffer, B. L. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity Neuropharmacology  2008 54:475-486  DOI:10.1016/j.neuropharm.2007.10.015  PMID:18082850
  • Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala Journal of Pharmacology and Experimental Therapeutics  2007 320:917-925  DOI:10.1124/jpet.106.112722  PMID:17114568
  • Contet, C., Dierich, A., Kieffer, B. L. Knock-in mice reveal nonsense-mediated mRNA decay in the brain Genesis  2007 45:38-43  DOI:10.1002/dvg.20263  PMID:17216605
  • Contet, C., Gaveriaux-Ruff, C., Matifas, A., Caradec, C., Champy, M. F., Kieffer, B. L. Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice Neuropsychopharmacology  2006 31:1733-1744  DOI:10.1038/sj.npp.1300934  PMID:16237385
  • Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene" Diabetes  2005 54:3510-3516  DOI:10.2337/diabetes.54.12.3510  PMID:16306369
  • Ghozland, S., Chu, K., Kieffer, B. L., Roberts, A. J. Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Neuropharmacology  2005 49:493-501  DOI:10.1016/j.neuropharm.2005.04.006  PMID:15961126
  • Grillet, N., Pattyn, A., Contet, C., Kieffer, B. L., Goridis, C., Brunet, J. F. Generation and characterization of Rgs4 mutant mice Molecular and Cellular Biology  2005 25:4221-4228  DOI:10.1128/mcb.25.10.4221-4228.2005  PMID:15870291  PMCID:PMC1087729
  • Contet, C., Kieffer, B. L., Befort, K. Mu opioid receptor: a gateway to drug addiction Current Opinion in Neurobiology  2004 14:370-378  DOI:10.1016/j.conb.2004.05.005  PMID:15194118
  • Contet, C., Matifas, A., Kieffer, B. L. No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse European Journal of Pharmacology  2004 492:131-136  DOI:10.1016/j.ejphar.2004.03.056  PMID:15178356
  • Scherrer, G., Befort, K., Contet, C., Becker, J., Matifas, A., Kieffer, B. L. The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice European Journal of Neuroscience  2004 19:2239-2248  DOI:10.1111/j.0953-816X.2004.03339.x  PMID:15090050
  • Koob, G. F., Roberts, A. J., Kieffer, B. L., Heyser, C. J., Katner, S. N., Ciccocioppo, R., Weiss, F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Recent Developments in Alcoholism  2003 16:263-281  DOI:10.1007/0-306-47939-7_19  PMID:12638642
  • Contarino, A., Picetti, R., Matthes, H. W., Koob, G. F., Kieffer, B. L., Gold, L. H. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice European Journal of Pharmacology  2002 446:103-109  DOI:10.1016/s0014-2999(02)01812-5  PMID:12098591
  • Roberts, A. J., Gold, L. H., Polis, L., McDonald, J. S., Filliol, D., Kieffer, B. L., Koob, G. F. Increased ethanol self-administration in delta-opioid receptor knockout mice Alcoholism-Clinical and Experimental Research  2001 25:1249-1256  DOI:10.1111/j.1530-0277.2001.tb02344.x  PMID:11584142
  • Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W. D., Koob, G. F., Gold, L. H. Mu-opioid receptor knockout mice do not self-administer alcohol Journal of Pharmacology and Experimental Therapeutics  2000 293:1002-1008  PMID:10869404