recent publications
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academic article
- Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala Journal of Pharmacology and Experimental Therapeutics 2015 355:206-211 DOI:10.1124/jpet.115.225870 PMID:26350161 PMCID:PMC4613963
- Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience 2014 17:1751-1758 DOI:10.1038/nn.3872 PMID:25402857 PMCID:PMC4241147
- Contet, C., Kim, A., Le, D., Iyengar, S. K., Kotzebue, R. W., Yuan, C. J., Kieffer, B. L., Mandyam, C. D. mu-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche Addiction Biology 2014 19:770-780 DOI:10.1111/adb.12040 PMID:23461397 PMCID:PMC3681911
- Cohen, A., Whitfield, T. W., Kreifeldt, M., Koebel, P., Kieffer, B. L., Contet, C., George, O., Koob, G. F. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization PLoS One 2014 9:e97216 DOI:10.1371/journal.pone.0097216 PMID:24816773 PMCID:PMC4016270
- Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Kappa-opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites Journal of Pharmacology and Experimental Therapeutics 2013 346:130-137 DOI:10.1124/jpet.112.202903 PMID:23587526 PMCID:PMC3684840
- Contet, C., Gardon, O., Filliol, D., Becker, J. A. J., Koob, G. F., Kieffer, B. L. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence Addiction Biology 2011 16:615-619 DOI:10.1111/j.1369-1600.2010.00304.x PMID:21392173 PMCID:PMC3139763
- Scherrer, G., Imamachi, N., Cao, Y. Q., Contet, C., Mennicken, F., O'Donnell, D., Kieffer, B. L., Basbaum, A. I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain Cell 2009 137:1148-1159 DOI:10.1016/j.cell.2009.04.019 PMID:19524516 PMCID:PMC3683597
- Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics 2009 328:284-293 DOI:10.1124/jpet.108.140749 PMID:18854491 PMCID:PMC2685907
- Contet, C., Filliol, D., Matifas, A., Kieffer, B. L. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity Neuropharmacology 2008 54:475-486 DOI:10.1016/j.neuropharm.2007.10.015 PMID:18082850
- Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala Journal of Pharmacology and Experimental Therapeutics 2007 320:917-925 DOI:10.1124/jpet.106.112722 PMID:17114568
- Contet, C., Dierich, A., Kieffer, B. L. Knock-in mice reveal nonsense-mediated mRNA decay in the brain Genesis 2007 45:38-43 DOI:10.1002/dvg.20263 PMID:17216605
- Contet, C., Gaveriaux-Ruff, C., Matifas, A., Caradec, C., Champy, M. F., Kieffer, B. L. Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice Neuropsychopharmacology 2006 31:1733-1744 DOI:10.1038/sj.npp.1300934 PMID:16237385
- Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene" Diabetes 2005 54:3510-3516 DOI:10.2337/diabetes.54.12.3510 PMID:16306369
- Ghozland, S., Chu, K., Kieffer, B. L., Roberts, A. J. Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Neuropharmacology 2005 49:493-501 DOI:10.1016/j.neuropharm.2005.04.006 PMID:15961126
- Grillet, N., Pattyn, A., Contet, C., Kieffer, B. L., Goridis, C., Brunet, J. F. Generation and characterization of Rgs4 mutant mice Molecular and Cellular Biology 2005 25:4221-4228 DOI:10.1128/mcb.25.10.4221-4228.2005 PMID:15870291 PMCID:PMC1087729
- Contet, C., Kieffer, B. L., Befort, K. Mu opioid receptor: a gateway to drug addiction Current Opinion in Neurobiology 2004 14:370-378 DOI:10.1016/j.conb.2004.05.005 PMID:15194118
- Contet, C., Matifas, A., Kieffer, B. L. No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse European Journal of Pharmacology 2004 492:131-136 DOI:10.1016/j.ejphar.2004.03.056 PMID:15178356
- Scherrer, G., Befort, K., Contet, C., Becker, J., Matifas, A., Kieffer, B. L. The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice European Journal of Neuroscience 2004 19:2239-2248 DOI:10.1111/j.0953-816X.2004.03339.x PMID:15090050
- Koob, G. F., Roberts, A. J., Kieffer, B. L., Heyser, C. J., Katner, S. N., Ciccocioppo, R., Weiss, F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Recent Developments in Alcoholism 2003 16:263-281 DOI:10.1007/0-306-47939-7_19 PMID:12638642
- Contarino, A., Picetti, R., Matthes, H. W., Koob, G. F., Kieffer, B. L., Gold, L. H. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice European Journal of Pharmacology 2002 446:103-109 DOI:10.1016/s0014-2999(02)01812-5 PMID:12098591
- Roberts, A. J., Gold, L. H., Polis, L., McDonald, J. S., Filliol, D., Kieffer, B. L., Koob, G. F. Increased ethanol self-administration in delta-opioid receptor knockout mice Alcoholism-Clinical and Experimental Research 2001 25:1249-1256 DOI:10.1111/j.1530-0277.2001.tb02344.x PMID:11584142
- Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W. D., Koob, G. F., Gold, L. H. Mu-opioid receptor knockout mice do not self-administer alcohol Journal of Pharmacology and Experimental Therapeutics 2000 293:1002-1008 PMID:10869404