Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Genetic dissection of the learning/memory gene dunce of Drosophila melanogaster

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Qiu, Y. H.
  • Davis, Ronald

publication date

  • July 1993

journal

  • Genes & Development  Journal

abstract

  • The dunce (dnc) gene of Drosophila melanogaster codes for cAMP phosphodiesterase (PDE) and is required for normal learning/memory and for female fertility. The expression of the gene is elevated in mushroom bodies, brain structures implicated in olfactory learning and memory. In this study several chromosomal deletions and inversions that remove increasingly larger portions of the dnc gene from its 5' end and progressively more of the five known transcription start sites (tss) were used to assess the functions of the various transcriptional units. Surprisingly, the dnc PDE activity, female fertility, mushroom body expression, learning, and memory were unaffected by the removal of tss1 and tss2. tss3 was required for elevated mushroom body expression but not for female fertility nor initial learning. tss4 contributed to learning and the female fertility function, whereas tss5 contributed to female fertility. The results indicate that the structural complexity of the gene is of biological significance, with individual transcriptional units serving different biological functions.

subject areas

  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Animals
  • Blotting, Northern
  • Chromosome Aberrations
  • Chromosome Disorders
  • Drosophila melanogaster
  • Female
  • Fertility
  • Genes
  • Immunohistochemistry
  • Learning
  • Male
  • Memory
  • RNA
  • Transcription, Genetic
scroll to property group menus

Research

keywords

  • CAMP PHOSPHODIESTERASE
  • DUNCE GENE
  • LEARNING MEMORY
  • MUSHROOM BODIES
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.7.7b.1447

PubMed ID

  • 7687228
scroll to property group menus

Additional Document Info

start page

  • 1447

end page

  • 1458

volume

  • 7

issue

  • 7B

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support