recent publications

• academic article

  • Bhattacharjee, G., Ahamed, J., Pawlinski, R., Liu, C., Mackman, N., Ruf, W., Edgington, T. S. Factor xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1 Circulation Research  2008 102:457-464  DOI:10.1161/circresaha.107.167759  PMID:18174463  PMCID:PMC2838720
  • Versteeg, H. H., Schaffner, F., Kerver, M., Petersen, H. H., Ahamed, J., Felding-Habermann, B., Takada, Y., Mueller, B. M., Ruf, W. Inhibition of tissue factor signaling suppresses tumor growth Blood  2008 111:190-199  DOI:10.1182/blood-2007-07-101048  PMID:17901245  PMCID:PMC2200804
  • Lawson, B. R., Manenkova, Y., Ahamed, J., Chen, X. R., Zou, J. P., Baccala, R., Theofilopoulos, A. N., Yuan, C. Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system Journal of Immunology  2007 178:5366-5374  PMID:17404322
  • Ahamed, J., Niessen, F., Kurokawa, T., Lee, Y. K., Bhattacharjee, G., Morrissey, J. H., Ruf, W. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia Blood  2007 109:5251-5259  DOI:10.1182/blood-2006-10-051334  PMID:17332247  PMCID:PMC1890821
  • Ahamed, J., Versteeg, H. H., Kerver, M., Chen, V. M., Mueller, B. M., Hogg, P. J., Ruf, W. Disulfide isomerization switches tissue factor from coagulation to cell signaling Proceedings of the National Academy of Sciences of the United States of America  2006 103:13932-13937  DOI:10.1073/pnas.0606411103  PMID:16959886  PMCID:PMC1599891
  • Chen, V. M., Ahamed, J., Versteeg, H. H., Berndt, M. C., Ruf, W., Hogg, P. J. Evidence for activation of tissue factor by an allosteric disulfide bond Biochemistry  2006 45:12020-12028  DOI:10.1021/bi061271a  PMID:17002301
  • Ahamed, J., Belting, M., Ruf, W. Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor Blood  2005 105:2384-2391  DOI:10.1182/blood-2004-09-3422  PMID:15550483
  • Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Liu, C., Edgington, T. S. Regulation of tissue factor-mediated initiation of the coagulation cascade by cell surface grp78 Arteriosclerosis, Thrombosis, and Vascular Biology  2005 25:1737-1743  DOI:10.1161/01.atv.0000173419.31242.56  PMID:15947236
  • Belting, M., Ahamed, J., Ruf, W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer Arteriosclerosis, Thrombosis, and Vascular Biology  2005 25:1545-1550  DOI:10.1161/01.ATV.0000171155.05809.bf  PMID:15905465
  • Ahamed, J., Ruf, W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain Journal of Biological Chemistry  2004 279:23038-23044  DOI:10.1074/jbc.M401376200  PMID:15039423
  • Belting, M., Dorrell, M. I., Sandgren, S., Aguilar, E., Ahamed, J., Dorfleutner, A., Carmeliet, P., Mueller, B. M., Friedlander, M., Ruf, W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling Nature Medicine  2004 10:502-509  DOI:10.1038/nm1037  PMID:15098027