recent publications

• academic article

  • Earnest, T. M., Lai, J., Chen, K., Hallock, M. J., Williamson, J. R., Luthey-Schulten, Z. Toward a whole-cell model of ribosome biogenesis: kinetic modeling of SSU assembly Biophysical Journal  2015 109:1117-1135  DOI:10.1016/j.bpj.2015.07.030  PMID:26333594  PMCID:PMC4576174
  • Fang, P., Han, H., Wang, J., Chen, K., Chen, X., Guo, M. Structural basis for specific inhibition of tRNA synthetase by an ATP competitive inhibitor Chemistry & Biology  2015 22:734-744  DOI:10.1016/j.chembiol.2015.05.007  PMID:26074468  PMCID:PMC4503318
  • Gavai, A. V., Quesnelle, C., Norris, D., Han, W. C., Gill, P., Shan, W., Balog, A., Chen, K., Tebben, A., Rampulla, R., Wu, D. R., Zhang, Y., et al. Discovery of clinical candidate BMS-906024: A potent pan-notch inhibitor for the treatment of leukemia and solid tumors ACS Medicinal Chemistry Letters  2015 6:523-527  DOI:10.1021/acsmedchemlett.5b00001  PMID:26005526  PMCID:PMC4434460
  • Fang, P., Yu, X., Jeong, S. J., Mirando, A., Chen, K., Chen, X., Kim, S., Francklyn, C. S., Guo, M. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase Nature Communications  2015 6:6402  DOI:10.1038/ncomms7402  PMID:25824639  PMCID:PMC4389257
  • Zhu, D., Yang, G., He, J., Chu, L., Chen, G., Gong, W., Chen, K., Eastgate, M. D., Yu, J. Q. Ligand-promoted ortho-C-H amination with Pd catalysts Angewandte Chemie-International Edition  2015 54:2497-2500  DOI:10.1002/anie.201408651  PMID:25598232
  • Lu, Y., Wang, H. W., Spangler, J. E., Chen, K., Cui, P. P., Zhao, Y., Sun, W. Y., Yu, J. Q. Rh(III)-catalyzed C-H olefination of N-pentafluoroaryl benzamides using air as the sole oxidant Chemical Science  2015 6:1923-1927  DOI:10.1039/c4sc03350g
  • Wengryniuk, S. E., Weickgenannt, A., Reiher, C., Strotman, N. A., Chen, K., Eastgate, M. D., Baran, P. S. Regioselective bromination of fused heterocyclic N-oxides Organic Letters  2013 15:792-795  DOI:10.1021/ol3034675  PMID:23350852
  • Chen, K., Ishihara, Y., Galan, M. M., Baran, P. S. Total synthesis of eudesmane terpenes: cyclase phase Tetrahedron  2010 66:4738-4744  DOI:10.1016/j.tet.2010.02.088
  • Guerrier, S., Coutinho-Budd, J., Sassa, T., Gresset, A., Jordan, N. V., Chen, K., Jin, W. L., Frost, A., Polleux, F. The f-bar domain of srgap2 induces membrane protrusions required for neuronal migration and morphogenesis Cell  2009 138:990-1004  DOI:10.1016/j.cell.2009.06.047  PMID:19737524  PMCID:PMC2797480
  • Chen, K., Baran, P. S. Total synthesis of eudesmane terpenes by site-selective C-H oxidations Nature  2009 459:824-828  DOI:10.1038/nature08043  PMID:19440196
  • Chen, K., Eschenmoser, A., Baran, P. S. Strain release in C-H bond activation? Angewandte Chemie-International Edition  2009 48:9705-9708  DOI:10.1002/anie.200904474  PMID:19937877  PMCID:PMC2879134
  • DeMartino, M. P., Chen, K., Baran, P. S. Intermolecular enolate heterocoupling: Scope, mechanism, and application Journal of the American Chemical Society  2008 130:11546-11560  DOI:10.1021/ja804159y  PMID:18680297
  • Chen, K., Richter, J. M., Baran, P. S. 1,3-diol synthesis via controlled, radical-mediated C-H functionalization Journal of the American Chemical Society  2008 130:7247-7249  DOI:10.1021/ja802491q  PMID:18481847
  • Young, J. A., Johnson, J. R., Benner, C., Yan, S. F., Chen, K., Le Roch, K. G., Zhou, Y. Y., Winzeler, E. A. In silico discovery of transcription regulatory elements in plasmodium falciparum BMC Genomics  2008 9:70  DOI:10.1186/1471-2164-9-70  PMID:18257930  PMCID:PMC2268928