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Amygdala kindling after ligation of the middle cerebral-artery in the rat

Academic Article
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Overview

authors

  • Schwartz, J. M.
  • Ehlers, Cindy
  • Detmer, W. M.
  • Bloom, Floyd

publication date

  • 1983

journal

  • Experimental Neurology  Journal

abstract

  • Cerebral infarcts were produced in rats by ligation of the right or left middle cerebral artery. A significant increase in seizure threshold and in the number of days required to develop kindled seizures was found in rats stimulated in the amygdala contralateral to the infarct. However, no significant changes in threshold or kindling rates were found in animals kindled ipsilateral to the ligation. These results were found to be independent of whether the infarct was in the right or left cerebral cortex. These data suggest that contralateral frontoparietal cerebral infarct may have inhibitory influences on seizures originating from the amygdala.

subject areas

  • Amygdala
  • Animals
  • Cerebral Cortex
  • Cerebral Infarction
  • Functional Laterality
  • Kindling, Neurologic
  • Male
  • Rats
  • Rats, Inbred Strains
  • Seizures
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Identity

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/0014-4886(83)90300-x

PubMed ID

  • 6840252
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Additional Document Info

start page

  • 484

end page

  • 490

volume

  • 80

issue

  • 2

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