Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

Academic Article
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publication date

  • December 2001

abstract

  • Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.