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Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins

Academic Article
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Overview

authors

  • Segal, D. J.
  • Barbas III, Carlos

publication date

  • December 2001

journal

  • Current Opinion in Biotechnology  Journal

abstract

  • Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

subject areas

  • Binding Sites
  • DNA-Binding Proteins
  • Gene Library
  • Genome
  • Genome, Human
  • Humans
  • Ligands
  • Models, Molecular
  • Protein Binding
  • Protein Structure, Tertiary
  • Recombinant Fusion Proteins
  • Zinc Fingers
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Identity

International Standard Serial Number (ISSN)

  • 0958-1669

Digital Object Identifier (DOI)

  • 10.1016/s0958-1669(01)00272-5

PubMed ID

  • 11849947
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Additional Document Info

start page

  • 632

end page

  • 637

volume

  • 12

issue

  • 6

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