recent publications
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academic article
- Reddick, J. J., Cheng, J. M., Roush, W. R. Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors Organic Letters 2003 5:1967-1970 DOI:10.1021/ol034555l PMID:12762698
- Roush, W. R., Cheng, J. M., Knapp-Reed, B., Alvarez-Hernandez, A., McKerrow, J. H., Hansell, E., Engel, J. C. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain Bioorganic & Medicinal Chemistry Letters 2001 11:2759-2762 DOI:10.1016/s0960-894x(01)00566-2 PMID:11591518
- Brinen, L. S., Hansell, E., Cheng, J. M., Roush, W. R., McKerrow, J. H., Fletterick, R. J. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease Structure with Folding & Design 2000 8:831-840 DOI:10.1016/s0969-2126(00)00173-8 PMID:10997902
- Roush, W. R., Gwaltney, S. L., Cheng, J. M., Scheidt, K. A., McKerrow, J. H., Hansell, E. Vinyl sulfonate esters and vinyl sulfonamides: potent, irreversible inhibitors of cysteine proteases Journal of the American Chemical Society 1998 120:10994-10995 DOI:10.1021/ja981792o