recent publications

• academic article

  • Reddick, J. J., Cheng, J. M., Roush, W. R. Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors Organic Letters  2003 5:1967-1970  DOI:10.1021/ol034555l  PMID:12762698
  • Roush, W. R., Cheng, J. M., Knapp-Reed, B., Alvarez-Hernandez, A., McKerrow, J. H., Hansell, E., Engel, J. C. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain Bioorganic & Medicinal Chemistry Letters  2001 11:2759-2762  DOI:10.1016/s0960-894x(01)00566-2  PMID:11591518
  • Brinen, L. S., Hansell, E., Cheng, J. M., Roush, W. R., McKerrow, J. H., Fletterick, R. J. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease Structure with Folding & Design  2000 8:831-840  DOI:10.1016/s0969-2126(00)00173-8  PMID:10997902
  • Roush, W. R., Gwaltney, S. L., Cheng, J. M., Scheidt, K. A., McKerrow, J. H., Hansell, E. Vinyl sulfonate esters and vinyl sulfonamides: potent, irreversible inhibitors of cysteine proteases Journal of the American Chemical Society  1998 120:10994-10995  DOI:10.1021/ja981792o