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Autoradiographic study of nmda-displaceable h-3 glutamate and h-3 mk-801 binding during butorphanol withdrawal in the rat brain

Academic Article
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Overview

authors

  • Jang, Choon-Gon
  • Park, Y.
  • Rockhold, R. W.
  • Ho, I. K.

publication date

  • October 1999

journal

  • Brain Research  Journal

abstract

  • Influences of continuous administration of butorphanol on the autoradiography of [3H]glutamate binding and [3H]MK-801 binding were investigated to study the effects of butorphanol withdrawal on NMDA receptors. Rats were administered butorphanol (26 nmol microl(-1) h(-1)) by continuous intracerebroventricular (i.c.v.) infusion through pre-implanted cannula connected to osmotic mini-pumps for 3 days. Rats were then sacrificed at 2, 7, and 24 h after discontinuation of butorphanol infusion. [3H]MK-801 binding was slightly increased in the cortical area, hippocampus, and cerebellum in 2, 7, and 24 h withdrawal groups and was shown most significant increase in the 7 h withdrawal group. NMDA-displaceable [3H]glutamate binding was markedly increased in the cortical area, striatum, septum, hippocampus, thalamus, and cerebellum in 7 h withdrawal group and was significantly increased in the striatum, hippocampus, and thalamus in 24 h withdrawal group. These results demonstrate that the development of butorphanol withdrawal is more prominent by 7 h after discontinuation of butorphanol infusion and suggest that NMDA binding sites at NMDA receptors may play more important role in the development of butorphanol withdrawal than that of channel blocking sites.

subject areas

  • Animals
  • Autoradiography
  • Binding, Competitive
  • Brain Chemistry
  • Butorphanol
  • Dizocilpine Maleate
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Glutamic Acid
  • Injections, Intraventricular
  • Male
  • N-Methylaspartate
  • Narcotic Antagonists
  • Rats
  • Rats, Sprague-Dawley
  • Substance Withdrawal Syndrome
  • Tritium
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Research

keywords

  • MK-801
  • NMDA
  • autoradiography
  • butorphanol
  • glutamate
  • withdrawal
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(99)01949-6

PubMed ID

  • 10536204
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Additional Document Info

start page

  • 236

end page

  • 241

volume

  • 845

issue

  • 2

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