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Cofilin phosphatases and regulation of actin dynamics

Academic Article
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Overview

authors

  • Huang, T. Y.
  • DerMardirossian, Celine
  • Bokoch, G. M.

publication date

  • February 2006

journal

  • Current Opinion in Cell Biology  Journal

abstract

  • Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.

subject areas

  • Actin Depolymerizing Factors
  • Actins
  • Animals
  • Humans
  • Hydrolases
  • Phosphoprotein Phosphatases
  • Phosphorylation
  • Tissue Distribution
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Identity

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/j.ceb.2005.11.005

PubMed ID

  • 16337782
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Additional Document Info

start page

  • 26

end page

  • 31

volume

  • 18

issue

  • 1

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