Cofilin phosphatases and regulation of actin dynamics

Academic Article

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Overview

authors

• Huang, T. Y.
• DerMardirossian, Celine
• Bokoch, G. M.

publication date

• February 2006

journal

• Current Opinion in Cell Biology  Journal

abstract

• Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.

subject areas

• Actin Depolymerizing Factors
• Actins
• Animals
• Humans
• Hydrolases
• Phosphoprotein Phosphatases
• Phosphorylation
• Tissue Distribution

Identity

International Standard Serial Number (ISSN)

• 0955-0674

Digital Object Identifier (DOI)

• 10.1016/j.ceb.2005.11.005

PubMed ID

• 16337782

Additional Document Info

start page

• 26

end page

• 31

volume

• 18

issue

• 1