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Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Academic Article
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Overview

related to degree

  • Kwok, Sen Wai, Ph.D. in Organic Chemistry, Scripps Research 2005 - 2011
  • Rodionov, Valentin, Ph.D. in Chemistry, Scripps Research 2002 - 2007

authors

  • Kwok, Sen Wai
  • Fotsing, J. R.
  • Fraser, R. J.
  • Rodionov, Valentin
  • Fokin, Valery

publication date

  • October 2010

journal

  • Organic Letters  Journal

abstract

  • 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

subject areas

  • Catalysis
  • Hydroxides
  • Molecular Structure
  • Transition Elements
  • Triazoles
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Identity

PubMed Central ID

  • PMC2946857

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol101568d

PubMed ID

  • 20825167
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Additional Document Info

start page

  • 4217

end page

  • 4219

volume

  • 12

issue

  • 19

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