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Effect of 6-hydroxydopamine lesions on norepinephrine-induced h-3 -labeled glycogen hydrolysis in mouse cortical slices

Academic Article
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Overview

authors

  • Magistretti, P. J.
  • Morrison, J. H.
  • Shoemaker, W. J.
  • Bloom, Floyd

publication date

  • 1983

journal

  • Brain Research  Journal

abstract

  • The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensitive response to NE was observed, as demonstrated by a decrease in the EC50 of the catecholamine in the lesioned mice from 533 +/- 88 nM to 39.3 +/- 7.9 nM. This supersensitive response, observed two weeks after the lesion, was post-synaptic since isoproterenol, a beta-adrenergic agonist not accumulated by pre-synaptic uptake mechanisms, also gave an equally supersensitive response.

subject areas

  • Adrenergic Fibers
  • Animals
  • Cerebral Cortex
  • Cyclic AMP
  • Energy Metabolism
  • Glycogen
  • Hydrolysis
  • Hydroxydopamines
  • Male
  • Muridae
  • Norepinephrine
  • Oxidopamine
  • Receptors, Adrenergic
  • Synapses
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(83)91297-0

PubMed ID

  • 6301624
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Additional Document Info

start page

  • 159

end page

  • 162

volume

  • 261

issue

  • 1

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