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Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior

Academic Article
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Overview

authors

  • Chen, A.
  • Zorrilla, Eric
  • Smith, S.
  • Rousso, D.
  • Levy, C.
  • Vaughan, J.
  • Donaldson, C.
  • Roberts, Amanda
  • Lee, K. F.
  • Vale, W.

publication date

  • May 2006

journal

  • Journal of Neuroscience  Journal

abstract

  • Gender differences in hypothalamus-pituitary-adrenal (HPA) axis activation and the prevalence of mood disorders are well documented. Urocortin 2, a recently identified member of the corticotropin-releasing factor family, is expressed in discrete neuroendocrine and stress-related nuclei of the rodent CNS. To determine the physiological role of urocortin 2, mice null for urocortin 2 were generated and HPA axis activity, ingestive, and stress-related behaviors and alterations in expression levels of CRF-related ligands and receptors were examined. Here we report that female, but not male, mice lacking urocortin 2 exhibit a significant increase in the basal daily rhythms of ACTH and corticosterone and a significant decrease in fluid intake and depressive-like behavior. The differential phenotype of urocortin 2 deficiency in female and male mice may imply a role for urocortin 2 in these gender differences.

subject areas

  • Adrenocorticotropic Hormone
  • Animals
  • Behavior, Animal
  • Brain
  • Cells, Cultured
  • Chimera
  • Circadian Rhythm
  • Corticosterone
  • Corticotropin-Releasing Hormone
  • Depressive Disorder
  • Disease Models, Animal
  • Drinking
  • Female
  • Hypothalamo-Hypophyseal System
  • Ligands
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Mutant Strains
  • Pituitary-Adrenal System
  • Sex Characteristics
  • Stress, Psychological
  • Urocortins
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Research

keywords

  • CRF/CRH
  • HPA axis
  • depression
  • gender differences
  • stress
  • urocortin 2
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Identity

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.3955-05.2006

PubMed ID

  • 16707802
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Additional Document Info

start page

  • 5500

end page

  • 5510

volume

  • 26

issue

  • 20

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