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Regulation of tissue factor gene-expression in the monocyte procoagulant response to endotoxin

Academic Article
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Overview

authors

  • Gregory, S. A.
  • Morrissey, J. H.
  • Edgington, Thomas

publication date

  • June 1989

journal

  • Molecular and Cellular Biology  Journal

abstract

  • Tissue factor is the cellular receptor and cofactor for plasma factor VIIa which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.

subject areas

  • Blotting, Northern
  • Cells, Cultured
  • Cycloheximide
  • DNA
  • DNA Probes
  • Gene Expression Regulation
  • Humans
  • Interferon-gamma
  • Interleukin-1
  • Interleukin-3
  • Lipopolysaccharides
  • Monocytes
  • RNA, Messenger
  • Recombinant Proteins
  • Thromboplastin
  • Tumor Necrosis Factor-alpha
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Identity

PubMed Central ID

  • PMC362351

International Standard Serial Number (ISSN)

  • 0270-7306

PubMed ID

  • 2503712
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Additional Document Info

start page

  • 2752

end page

  • 2755

volume

  • 9

issue

  • 6

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