recent publications
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academic article
- Spraggon, G., Hornsby, M., Shipway, A., Tully, D. C., Bursulaya, B., Danahay, H., Harris, J. L., Lesley, S. A. Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations Protein Science 2009 18:1081-1094 DOI:10.1002/pro.118 PMID:19388054 PMCID:PMC2771310
- Inagaki, H., Tsuruoka, H., Hornsby, M., Lesley, S. A., Spraggon, G., Ellman, J. A. Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode Journal of Medicinal Chemistry 2007 50:2693-2699 DOI:10.1021/jm070111+ PMID:17469812
- Xu, Q. P., Schwarzenbacher, R., Krishna, S. S., McMullan, D., Agarwalla, S., Quijano, K., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., et al. Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 a resolution Proteins-Structure Function and Bioinformatics 2006 64:808-813 DOI:10.1002/prot.20947 PMID:16783794
- Jin, K. K., Krishna, S. S., Schwarzenbacher, R., McMullan, D., Abdubek, P., Agarwalla, S., Ambing, E., Axelrod, H., Canaves, J. M., Chiu, H. J., Deacon, A. M., DiDonato, M., et al. Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold Proteins-Structure Function and Bioinformatics 2006 63:1112-1118 DOI:10.1002/prot.20894 PMID:16544291
- DiDonato, M., Krishna, S. S., Schwarzenbacher, R., McMullan, D., Jaroszewski, L., Miller, M. D., Abdubek, M., Agarwalla, S., Ambing, E., Axelrod, H., Biorac, T., Chiu, H. J., et al. Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 a resolution Proteins-Structure Function and Bioinformatics 2006 63:256-260 DOI:10.1002/prot.20841 PMID:16435371
- Xu, Q. P., Schwarzenbacher, R., McMullan, D., Abdubek, P., Agarwalla, S., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chin, H. J., Deacon, A. M., DiDonato, M., et al. Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 Å resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2006 62:292-296 DOI:10.1002/prot.20611 PMID:16287129
- Han, S. L., Zhou, V., Pan, S. F., Liu, Y., Hornsby, M., McMullan, D., Klock, H. E., Haugen, J., Lesley, S. A., Gray, T., Caldwell, J., Gu, X. J. Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors Bioorganic & Medicinal Chemistry Letters 2005 15:5467-5473 DOI:10.1016/j.bmcl.2005.08.097 PMID:16199156
- Klock, H. E., Schwarzenbacher, R., Xu, Q. P., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., Deacon, A. M., DiDonato, M., et al. Crystal structure of a conserved hypothetical protein (gi : 13879369) from Mouse at 1.90 A resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2005 61:1132-1136 DOI:10.1002/prot.20610 PMID:16224779
- Jaroszewski, L., Schwarzenbacher, R., McMullan, D., Abdubek, P., Agarwalla, S., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., Deacon, A. M., DiDonato, M., et al. Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 Å resolution Proteins-Structure Function and Bioinformatics 2005 61:669-673 DOI:10.1002/prot.20542 PMID:16167343
- Rife, C., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., Deacon, A. M., DiDonato, M., Elsliger, M. A., et al. Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 Å resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2005 61:444-448 DOI:10.1002/prot.20468 PMID:16104019
- Rife, C., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., Deacon, A. M., DiDonato, M., Elsliger, M. A., et al. Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2005 61:449-453 DOI:10.1002/prot.20502 PMID:16104018
- Han, G. W., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., Dai, X. P., Deacon, A. M., DiDonato, M., et al. Crystal structure of an Apo mRNA decapping enzyme (DcpS) from mouse at 1.83 Å resolution Proteins-Structure Function and Bioinformatics 2005 60:797-802 DOI:10.1002/prot.20467 PMID:16001405
- Mathews, I., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J. M., Chiu, H. J., Deacon, C. M., DiDonato, M., Elsliger, M. A., et al. Crystal structure of S-adenosylmethionine : tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2005 59:869-874 DOI:10.1002/prot.20419 PMID:15822125
- Levin, I., Miller, M. D., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Biorac, T., Cambell, J., Canaves, J. M., Chiu, C. J., Deacon, A. M., DiDonato, M., et al. Crystal structure of an indigoidine synthase A (IndA)-like protein (TM64) from Thermotoga maritima at 1.90 A resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2005 59:864-868 DOI:10.1002/prot.20420 PMID:15822122
- Xu, Q. P., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Bioac, T., Canaves, J. M., Chiu, H. J., Dai, X. P., Deacon, D. M., DiDonato, M., Elsliger, M. A., et al. Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold Proteins-Structure Function and Bioinformatics 2005 58:976-981 DOI:10.1002/prot.20364 PMID:15651027
- Han, G. W., Schwarzenbacher, R., Page, R., Jaroszewski, L., Abdubek, P., Ambing, E., Biorac, T., Canaves, J. M., Chiu, H. J., Dai, X. P., Deacon, D. M., DiDonato, M., et al. Crystal structure of an alanine-glyoxylate aminotransferase from anabaena sp at 1.70 A resolution reveals a noncovalently linked PLP cofactor Proteins-Structure Function and Bioinformatics 2005 58:971-975 PMID:15657930
- Arndt, J. W., Schwarzenbacher, R., Page, R., Abdubek, P., Ambing, E., Biorac, T., Canaves, J. M., Chiu, H. J., Dai, X. P., Deacon, A. M., DiDonato, M., Elsliger, M. A., et al. Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution Proteins-Structure Function and Bioinformatics 2005 58:755-758 DOI:10.1002/prot.20336 PMID:15624212