recent publications

• academic article

  • Dreyton, C. J., Knuckley, B., Jones, J. E., Lewallen, D. M., Thompson, P. R. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism Biochemistry  2014 53:4426-4433  DOI:10.1021/bi500554b  PMID:24989433  PMCID:PMC4100781
  • Dwivedi, N., Upadhyay, J., Neeli, I., Khan, S., Pattanaik, D., Myers, L., Kirou, K. A., Hellmich, B., Knuckley, B., Thompson, P. R., Crow, M. K., Mikuls, T. R., et al. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps Arthritis and Rheumatism  2012 64:982-992  DOI:10.1002/art.33432  PMID:22034172  PMCID:PMC4729190
  • Lewallen, D. M., Steckler, C. J., Knuckley, B., Chalmers, M. J., Thompson, P. R. Probing adenylation: Using a fluorescently labelled atp probe to directly label and immunoprecipitate vops substrates Molecular Biosystems  2012 8:1701-1706  DOI:10.1039/c2mb25053e  PMID:22456874
  • Willis, V., Gizinski, A. M., Banda, N. K., Causey, C. P., Knuckley, B., Cordova, K. N., Luo, Y. A., Levitt, B., Glogowska, M., Chandra, P., Kulik, L., Robinson, W. H., et al. N-alpha-benzoyl-n5-(2-chloro-1-iminoethyl)-l-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis Journal of Immunology  2011 186:4396-4404  DOI:10.4049/jimmunol.1001620  PMID:21346230  PMCID:PMC3085980
  • Causey, C. P., Jones, J. E., Slack, J. L., Kamei, D., Jones, L. E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A. A., Luo, Y., Hashimoto, H., Sato, M., et al. The development of n-alpha-(2-carboxyl)benzoyl-n(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-f-amidine) and n-alpha-(2-carboxyl)benzoyl-n(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-cl-amidine) as second generation protein arginine deiminase (pad) inhibitors Journal of Medicinal Chemistry  2011 54:6919-6935  DOI:10.1021/jm2008985  PMID:21882827  PMCID:PMC3196593
  • Knuckley, B., Jones, J. E., Bachovchin, D. A., Slack, J., Causey, C. P., Brown, S. J., Rosen, H., Cravatt, B. F., Thompson, P. R. A fluopol-ABPP HTS assay to identify PAD inhibitors Chemical Communications  2010 46:7175-7177  DOI:10.1039/c0cc02634d  PMID:20740228  PMCID:PMC2943038
  • Jones, J. E., Causey, C. P., Lovelace, L., Knuckley, B., Flick, H., Lebioda, L., Thompson, P. R. Characterization and inactivation of an agmatine deiminase from helicobacter pylori Bioorganic Chemistry  2010 38:62-73  DOI:10.1016/j.bioorg.2009.11.004  PMID:20036411  PMCID:PMC2823940
  • Knuckley, B., Causey, C. P., Pellechia, P. J., Cook, P. F., Thompson, P. R. Haloacetamidine-based inactivators of protein arginine deiminase 4 (pad4): Evidence that general acid catalysis promotes efficient inactivation ChemBioChem  2010 11:161-165  DOI:10.1002/cbic.200900698  PMID:20014086  PMCID:PMC3056394
  • Knuckley, B., Causey, C. P., Jones, J. E., Bhatia, M., Dreyton, C. J., Osborne, T. C., Takahara, H., Thompson, P. R. Substrate specificity and kinetic studies of pads 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3 Biochemistry  2010 49:4852-4863  DOI:10.1021/bi100363t  PMID:20469888  PMCID:PMC2884139
  • Jones, J. E., Causey, C. P., Knuckley, B., Slack-Noyes, J. L., Thompson, P. R. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Current Opinion in Drug Discovery & Development  2009 12:616-627  PMID:19736621  PMCID:PMC3771078
  • Knuckley, B., Luo, Y., Thompson, P. R. Profiling protein arginine deiminase 4 (pad4): A novel screen to identify pad4 inhibitors Bioorganic & Medicinal Chemistry  2008 16:739-745  DOI:10.1016/j.bmc.2007.10.021  PMID:17964793  PMCID:PMC2267747
  • Knuckley, B., Bhatia, M., Thompson, P. R. Protein arginine deiminase 4: Evidence for a reverse protonation mechanism Biochemistry  2007 46:6578-6587  DOI:10.1021/bi700095s  PMID:17497940  PMCID:PMC2212595
  • Luo, Y., Knuckley, B., Lee, Y. H., Stallcup, M. R., Thompson, P. R. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation Journal of the American Chemical Society  2006 128:1092-1093  DOI:10.1021/ja0576233  PMID:16433522  PMCID:PMC1850713
  • Luo, Y., Knuckley, B., Bhatia, M., Pellechia, P. J., Thompson, P. R. Activity-based protein profiling reagents for protein arginine deiminase 4 (pad4): Synthesis and in vitro evaluation of a fluorescently labeled probe Journal of the American Chemical Society  2006 128:14468-14469  DOI:10.1021/ja0656907  PMID:17090024  PMCID:PMC2234596
  • Luo, Y., Arita, K., Bhatia, M., Knuckley, B., Lee, Y. H., Stallcup, M. R., Sato, M., Thompson, P. R. Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization Biochemistry  2006 45:11727-11736  DOI:10.1021/bi061180d  PMID:17002273  PMCID:PMC1808342