recent publications
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academic article
- Dreyton, C. J., Knuckley, B., Jones, J. E., Lewallen, D. M., Thompson, P. R. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism Biochemistry 2014 53:4426-4433 DOI:10.1021/bi500554b PMID:24989433 PMCID:PMC4100781
- Dwivedi, N., Upadhyay, J., Neeli, I., Khan, S., Pattanaik, D., Myers, L., Kirou, K. A., Hellmich, B., Knuckley, B., Thompson, P. R., Crow, M. K., Mikuls, T. R., et al. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps Arthritis and Rheumatism 2012 64:982-992 DOI:10.1002/art.33432 PMID:22034172 PMCID:PMC4729190
- Lewallen, D. M., Steckler, C. J., Knuckley, B., Chalmers, M. J., Thompson, P. R. Probing adenylation: Using a fluorescently labelled atp probe to directly label and immunoprecipitate vops substrates Molecular Biosystems 2012 8:1701-1706 DOI:10.1039/c2mb25053e PMID:22456874
- Willis, V., Gizinski, A. M., Banda, N. K., Causey, C. P., Knuckley, B., Cordova, K. N., Luo, Y. A., Levitt, B., Glogowska, M., Chandra, P., Kulik, L., Robinson, W. H., et al. N-alpha-benzoyl-n5-(2-chloro-1-iminoethyl)-l-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis Journal of Immunology 2011 186:4396-4404 DOI:10.4049/jimmunol.1001620 PMID:21346230 PMCID:PMC3085980
- Causey, C. P., Jones, J. E., Slack, J. L., Kamei, D., Jones, L. E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A. A., Luo, Y., Hashimoto, H., Sato, M., et al. The development of n-alpha-(2-carboxyl)benzoyl-n(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-f-amidine) and n-alpha-(2-carboxyl)benzoyl-n(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-cl-amidine) as second generation protein arginine deiminase (pad) inhibitors Journal of Medicinal Chemistry 2011 54:6919-6935 DOI:10.1021/jm2008985 PMID:21882827 PMCID:PMC3196593
- Knuckley, B., Causey, C. P., Jones, J. E., Bhatia, M., Dreyton, C. J., Osborne, T. C., Takahara, H., Thompson, P. R. Substrate specificity and kinetic studies of pads 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3 Biochemistry 2010 49:4852-4863 DOI:10.1021/bi100363t PMID:20469888 PMCID:PMC2884139
- Jones, J. E., Causey, C. P., Lovelace, L., Knuckley, B., Flick, H., Lebioda, L., Thompson, P. R. Characterization and inactivation of an agmatine deiminase from helicobacter pylori Bioorganic Chemistry 2010 38:62-73 DOI:10.1016/j.bioorg.2009.11.004 PMID:20036411 PMCID:PMC2823940
- Knuckley, B., Causey, C. P., Pellechia, P. J., Cook, P. F., Thompson, P. R. Haloacetamidine-based inactivators of protein arginine deiminase 4 (pad4): Evidence that general acid catalysis promotes efficient inactivation ChemBioChem 2010 11:161-165 DOI:10.1002/cbic.200900698 PMID:20014086 PMCID:PMC3056394
- Knuckley, B., Jones, J. E., Bachovchin, D. A., Slack, J., Causey, C. P., Brown, S. J., Rosen, H., Cravatt, B. F., Thompson, P. R. A fluopol-ABPP HTS assay to identify PAD inhibitors Chemical Communications 2010 46:7175-7177 DOI:10.1039/c0cc02634d PMID:20740228 PMCID:PMC2943038
- Jones, J. E., Causey, C. P., Knuckley, B., Slack-Noyes, J. L., Thompson, P. R. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential Current Opinion in Drug Discovery & Development 2009 12:616-627 PMID:19736621 PMCID:PMC3771078
- Knuckley, B., Luo, Y., Thompson, P. R. Profiling protein arginine deiminase 4 (pad4): A novel screen to identify pad4 inhibitors Bioorganic & Medicinal Chemistry 2008 16:739-745 DOI:10.1016/j.bmc.2007.10.021 PMID:17964793 PMCID:PMC2267747
- Knuckley, B., Bhatia, M., Thompson, P. R. Protein arginine deiminase 4: Evidence for a reverse protonation mechanism Biochemistry 2007 46:6578-6587 DOI:10.1021/bi700095s PMID:17497940 PMCID:PMC2212595
- Luo, Y., Knuckley, B., Bhatia, M., Pellechia, P. J., Thompson, P. R. Activity-based protein profiling reagents for protein arginine deiminase 4 (pad4): Synthesis and in vitro evaluation of a fluorescently labeled probe Journal of the American Chemical Society 2006 128:14468-14469 DOI:10.1021/ja0656907 PMID:17090024 PMCID:PMC2234596
- Luo, Y., Arita, K., Bhatia, M., Knuckley, B., Lee, Y. H., Stallcup, M. R., Sato, M., Thompson, P. R. Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization Biochemistry 2006 45:11727-11736 DOI:10.1021/bi061180d PMID:17002273 PMCID:PMC1808342
- Luo, Y., Knuckley, B., Lee, Y. H., Stallcup, M. R., Thompson, P. R. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation Journal of the American Chemical Society 2006 128:1092-1093 DOI:10.1021/ja0576233 PMID:16433522 PMCID:PMC1850713