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Selection of tcr v-alpha by mhc class-ii predicts superantigen reactivity

Academic Article
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Overview

authors

  • Alam, S. M.
  • Sim, B. C.
  • Gascoigne, Nicholas

publication date

  • August 1995

journal

  • International Immunology  Journal

abstract

  • Recognition of superantigens by T cells predominantly involves the TCR V beta region. The contribution of reactivity from the non-V beta portion of the TCR remains less clear. We have investigated the V alpha repertoire of T cells bearing one V beta element responding to different superantigen or polyclonal stimuli. The data indicate that the V alpha chain is not directly involved in superantigen recognition, since unrelated superantigens do not stimulate cells bearing different V alpha elements. Instead, analysis of V alpha elements used preferentially in the CD4+ or CD8+ cells, shows that the V alpha-regions predominating in the superantigen response are the same V alphas that are positively selected into the CD4+ lineage. Thus the ability of a V alpha-region to either aid or hinder the interaction with class II predicts its frequency in a superantigen-responding population of T cells.

subject areas

  • Animals
  • Antigens, Viral
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Enterotoxins
  • Genes, MHC Class II
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Receptors, Antigen, T-Cell, alpha-beta
  • Retroviridae
  • Staphylococcus aureus
  • Superantigens
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Research

keywords

  • ALPHA-CHAIN
  • POSITIVE SELECTION
  • SUPERANTIGEN
  • T CELL RECOGNITION
  • TCR
  • V-ALPHA
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Identity

International Standard Serial Number (ISSN)

  • 0953-8178

Digital Object Identifier (DOI)

  • 10.1093/intimm/7.8.1311

PubMed ID

  • 7495738
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Additional Document Info

start page

  • 1311

end page

  • 1318

volume

  • 7

issue

  • 8

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