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Microvascular abnormalities as possible predictors of disease subsets in Raynaud phenomenon and early connective tissue disease

Academic Article
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Overview

authors

  • Maricq, H. R.
  • Harper, F. E.
  • Khan, M. M.
  • Tan, Eng
  • Leroy, E. C.

publication date

  • 1983

journal

  • Clinical and Experimental Rheumatology  Journal

abstract

  • In vivo capillary examination was performed on 80 patients included in a prospective study of Raynaud phenomenon (RP): 40 RP only (RPO), 20 undifferentiated connective tissue disease (UCTD) and 20 systemic scleroderma (SD) of less than 5 years' duration. On initial examination, SD-pattern capillary abnormalities were found in 7/40 patients with RP alone, 18/20 with UCTD and 19/20 with SD. On follow-up a change of diagnosis into a definite connective tissue disease occurred in 4 patients with UCTD; one patient with RP alone died with symptoms of myositis and fulminant pulmonary vasculitis. All five showed SD-pattern capillary abnormalities of the "active" type on initial examination. A significant correlation between the "slow" capillary pattern and the presence of anticentromere antibodies was also observed. Only one patient of 25 RPO with normal capillaries available for follow-up showed any change in clinical status.

subject areas

  • Antibodies, Antinuclear
  • Capillaries
  • Connective Tissue Diseases
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Nails
  • Prognosis
  • Prospective Studies
  • Raynaud Disease
  • Scleroderma, Systemic
  • Skin
  • Telangiectasis
  • Venules
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Identity

International Standard Serial Number (ISSN)

  • 0392-856X

PubMed ID

  • 6335855
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Additional Document Info

start page

  • 195

end page

  • 205

volume

  • 1

issue

  • 3

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