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Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II

Academic Article
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Overview

authors

  • Homann, D.
  • Lewicki, H.
  • Brooks, D.
  • Eberlein, J.
  • Mallet-Designe, V.
  • Teyton, Luc
  • Oldstone, Michael

publication date

  • June 2007

journal

  • Virology  Journal

abstract

  • Virus-specific CD4(+) T cells contribute to effective virus control through a multiplicity of mechanisms including direct effector functions as well as "help" for B cell and CD8(+) T cell responses. Here, we have used the lymphocytic choriomeningitis virus (LCMV) system to assess the minimal constraints of a dominant antiviral CD4(+) T cell response. We report that the core epitope derived from the LCMV glycoprotein (GP) is 11 amino acids in length and provides optimal recognition by epitope-specific CD4(+) T cells. Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction.

subject areas

  • Amino Acid Sequence
  • Animals
  • CD4-Positive T-Lymphocytes
  • Epitope Mapping
  • Epitopes, T-Lymphocyte
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Immunodominant Epitopes
  • Lymphocytic choriomeningitis virus
  • Mice
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes, Cytotoxic
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Research

keywords

  • CD4
  • CD8
  • LCMV
  • MHC class I
  • MHC class II
  • T cell response
  • virus
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Identity

PubMed Central ID

  • PMC1976554

International Standard Serial Number (ISSN)

  • 0042-6822

Digital Object Identifier (DOI)

  • 10.1016/j.virol.2006.12.025

PubMed ID

  • 17320138
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Additional Document Info

start page

  • 113

end page

  • 123

volume

  • 363

issue

  • 1

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