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Spatial navigation and causal analysis in a brain-based device modeling cortical-hippocampal interactions

Academic Article
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Overview

authors

  • Krichmar, J. L.
  • Seth, A. K.
  • Nitz, D. A.
  • Fleischer, J. G.
  • Edelman, Gerald

publication date

  • 2005

journal

  • Neuroinformatics  Journal

abstract

  • We describe Darwin X, a physical device that interacts with a real environment, whose behavior is guided by a simulated nervous system incorporating aspects of the detailed anatomy and physiology of the hippocampus and its surrounding regions. This brain-based device integrates cues from its environment and solves a spatial memory task. The responses of simulated neuronal units in the hippocampal areas during its exploratory behavior are comparable to place cells in the rodent hippocampus and emerged by associating sensory cues during exploration. To identify different functional hippocampal pathways and their influence on behavior, we employed a time series analysis that distinguishes causal interactions within and between simulated hippocampal and neocortical regions while the device is engaged in a spatial memory task. Our analysis identified different functional pathways within the neural simulation and prompts novel predictions about the influence of the perforant path, the trisynaptic loop and hippocampal-cortical interactions on place cell activity and behavior during navigation. Moreover, this causal time series analysis may be useful in analyzing networks in general.

subject areas

  • Animals
  • Artificial Intelligence
  • Behavior, Animal
  • Cerebral Cortex
  • Computer Simulation
  • Hippocampus
  • Humans
  • Models, Neurological
  • Neural Networks (Computer)
  • Space Perception
  • Spatial Behavior
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Research

keywords

  • episodic memory
  • granger causality
  • perforant pathway
  • place cell
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Identity

International Standard Serial Number (ISSN)

  • 1539-2791

Digital Object Identifier (DOI)

  • 10.1385/ni:3:3:197

PubMed ID

  • 16077159
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Additional Document Info

start page

  • 197

end page

  • 221

volume

  • 3

issue

  • 3

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