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Cellular and molecular heterogeneity of h-2kk antigens

Academic Article
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Overview

authors

  • Eskinazi, D. P.
  • Molinaro, G. A.
  • Reisfeld, Ralph
  • Ferrone, S.

publication date

  • 1981

journal

  • Journal of Immunogenetics  Journal

abstract

  • Up to 70% of mouse spleen cells expressing H-2Kk alloantigens reacted with the monoclonal anti-H-2Kk antibody 11-4.1 in an indirect rosetting assay. When the cells that rosetted with the monoclonal antibody 11-4.1 were removed by density centrifugation, the residual unreactive cells reacted with the polyclonal anti-H-2Kk alloantiserum D23 but not with the monoclonal antibody 11-4.1 indicating the existence of two cel populations. In sequential immunoprecipitation experiments, the glycoprotein fraction of NP40 extracts from H-2Kk cells, after removal of antigens reacting with the monoclonal antibody 11-4.1 still contained structures reactive with the alloantiserum. Therefore, there are at least two antigenically distinct H-2Kk molecules which are differentially expressed on two subpopulations of spleen cells.

subject areas

  • Animals
  • Antibody Specificity
  • Clone Cells
  • Glycoproteins
  • H-2 Antigens
  • Hybrid Cells
  • Isoantibodies
  • Mice
  • Rosette Formation
  • Spleen
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Identity

International Standard Serial Number (ISSN)

  • 0305-1811

PubMed ID

  • 7229421
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Additional Document Info

start page

  • 101

end page

  • 106

volume

  • 8

issue

  • 2

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