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Distribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in swedish caucasians and Hong Kong Chinese

Academic Article
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Overview

authors

  • Padyukov, L.
  • Hahn-Zoric, M.
  • Blomqvist, S. R.
  • Ulanova, M.
  • Welch, S. G.
  • Feeney, Ann
  • Lau, Y. L.
  • Hanson, L. A.

publication date

  • February 2001

journal

  • Immunogenetics  Journal

abstract

  • Polymorphism in the IGKV2-29 gene was shown to decrease the recombination frequency in B cells and to be important for immune responses to Haemophilus influenzae type b polysaccharide. By using the combination of PCR and restriction enzyme mapping, the distribution of IGKV2D-29 and IGKV2-29 gene alleles was estimated in two geographically and ethnically different groups. We found that V2D-29*01 homozygous individuals were most common in Swedish Caucasians (82%), but less common in the Chinese population of Hong Kong (28%). The homozygous V2D-29*02 genotype was found in 19% Chinese, but only in one Caucasian (1%). The frequency of the heterozygous V2D-29*01/V2D-29*02 genotype was also higher in the Chinese population (46%) compared with the Caucasians (7%). V2-29*01 homozygosity was more frequent among Caucasians (85%) than among Chinese (19%). In contrast, homozygous V2-29*02 individuals were over-represented in the Chinese population (18%), whereas only one was found among Caucasians (1%). Heterozygous V2-29*01/V2-29*02 individuals were also more common in the Chinese (63%) than the Caucasian (15%) population. Most Caucasians had the combination of V2D-29*01/V2D-29*01+V2-29*01/V2-29*01 (74%), while the most common genotype for Chinese was V2D-29*01/V2D-29*02+ V2-29*01/V2-29*02 (41%). Analysis of the association of V2D-29*02 and V2-29*02 alleles demonstrated a high degree of linkage, as for V2D-29*01 with V2-29*01. These data show a significant difference in the distribution of IGKV2D-29 and IGKV2-29 alleles among Swedish Caucasians and Hong Kong Chinese. This may help to explain differences in the occurrence of H. influenzae type b infection in the two populations. Evaluated methods for IGKV2D-29 and IGKV2-29 allele detection can be used for the screening allele polymorphisms in other particular patient groups.

subject areas

  • Alleles
  • Asian Continental Ancestry Group
  • China
  • European Continental Ancestry Group
  • Gene Frequency
  • Genes, Immunoglobulin
  • Hong Kong
  • Humans
  • Immunoglobulin Variable Region
  • Immunoglobulins
  • Sweden
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Research

keywords

  • Haemophilus influenzae
  • IGKV2-29
  • IGKV2D-29
  • gene polymorphism
  • kappa locus
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Identity

International Standard Serial Number (ISSN)

  • 0093-7711

Digital Object Identifier (DOI)

  • 10.1007/s002510000291

PubMed ID

  • 11261927
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Additional Document Info

start page

  • 22

end page

  • 30

volume

  • 53

issue

  • 1

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