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T cell-independent rescue of b lymphocytes from peripheral immune tolerance

Academic Article
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Overview

authors

  • Kouskoff, V.
  • Lacaud, G.
  • Nemazee, David

publication date

  • March 2000

journal

  • Science  Journal

abstract

  • Autoimmunity arises when immune tolerance to specific self-antigens is broken. The mechanisms leading to such a failure remain poorly understood. One hypothesis proposes that infectious agents or antigens can break B or T lymphocyte self-tolerance by expressing epitopes that mimic self. Using a transgenic immunoglobulin model, we show that challenge with self-mimicking foreign antigen rescues B cells from peripheral tolerance independent of T cell help, resulting in the accumulation of self-reactive cells in the lymph nodes and secretion of immunoglobulins that bind to a liver-expressed self-antigen. Therefore, our studies reveal a potentially important mechanism by which B lymphocytes can escape self-tolerance.

subject areas

  • Animals
  • Antigens, T-Independent
  • Autoantibodies
  • Autoantigens
  • B-Lymphocytes
  • Bone Marrow
  • Clonal Deletion
  • Cross Reactions
  • H-2 Antigens
  • Immunization
  • Immunoglobulin M
  • Liver
  • Lymph Nodes
  • Lymphocyte Activation
  • Mice
  • Mice, Transgenic
  • Molecular Mimicry
  • Receptors, Antigen, B-Cell
  • Self Tolerance
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.287.5462.2501

PubMed ID

  • 10741972
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Additional Document Info

start page

  • 2501

end page

  • 2503

volume

  • 287

issue

  • 5462

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