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C3-mediated cytoadherence - formation of c3 receptor aggregates as prerequisite for cell attachment

Academic Article
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Overview

authors

  • Dierich, M. P.
  • Reisfeld, Ralph

publication date

  • 1975

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Inhibition of free movement of C3 receptors by either applying low temperature (3 degrees C) or fixing the cell surfce of lymphocytes with glutaraldehyde (2 times 10(-5) to 2 times 10(-1)%) results in loss of firm attachment of EAC142 3b cells to the lympocytes as demonstrated here by loss of rosette formation of Raji lymphoid cells. Under the same conditions soluble C3 can still bind but is unable to induce aggregation of C3 receptors into small patches. It is suggested that the local increase of C3 receptor density by aggregation is a prerequisite for C3-dependent cytoadherence. Microaggregation of corresponding receptor sites may be essential also in other recognition systems.

subject areas

  • Animals
  • Antigens
  • Binding Sites
  • Cell Adhesion
  • Cell Membrane
  • Cold Temperature
  • Complement C3
  • Complement System Proteins
  • Erythrocytes
  • Fluorescent Antibody Technique
  • Glutaral
  • Humans
  • Lymphocytes
  • Sheep
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.142.1.242

PubMed ID

  • 807673
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Additional Document Info

start page

  • 242

end page

  • 247

volume

  • 142

issue

  • 1

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