recent publications
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academic article
- Bhatt, D. L., Pare, G., Eikelboom, J. W., Simonsen, K. L., Emison, E. S., Fox, K. A. A., Steg, P. G., Montalescot, G., Bhakta, N., Hacke, W., Flather, M. D., Mak, K. H., et al. The relationship between cyp2c19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: The charisma genetics study European Heart Journal 2012 33:2143-2150 DOI:10.1093/eurheartj/ehs059 PMID:22450429
- Berger, J. S., Bhatt, D. L., Steg, P. G., Steinhubl, S. R., Montalescot, G., Shao, M. Y., Hacke, W., Fox, K. A., Berger, P. B., Topol, E. J., Lincoff, A. M., Investigators, Charisma Bleeding, mortality, and antiplatelet therapy: Results from the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (charisma) trial American Heart Journal 2011 162:98-105 DOI:10.1016/j.ahj.2011.04.015 PMID:21742095
- Hankey, G. J., Johnston, S. C., Easton, J. D., Hacke, W., Mas, J. L., Brennan, D., Mak, K. H., Bhatt, D. L., Fox, K. A. A., Topol, E. J., Investigators, Charisma Trial Effect of clopidogrel plus asa vs. Asa early after tia and ischaemic stroke: A substudy of the charisma trial International Journal of Stroke 2011 6:3-9 DOI:10.1111/j.1747-4949.2010.00535.x PMID:21205234
- Hankey, G. J., Hacke, W., Easton, J. D., Johnston, S. C., Mas, J. L., Brennan, D. M., Bhatt, D. L., Fox, K. A. A., Topol, E. J., Investigators, Charisma Trial Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients a prespecified substudy of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management and avoidance (charisma) trial Stroke 2010 41:1679-1683 DOI:10.1161/strokeaha.110.586727 PMID:20595658
- Berger, P. B., Bhatt, D. L., Fuster, V., Steg, P. G., Fox, K. A. A., Shao, M. Y., Brennan, D. M., Hacke, W., Montalescot, G., Steinhubl, S. R., Topol, E. J., Investigators, Charisma Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease Circulation 2010 121:2575-2583 DOI:10.1161/circulationaha.109.895342 PMID:20516378
- Berger, J. S., Bhatt, D. L., Steinhubl, S. R., Shao, M. Y., Steg, P. G., Montalescot, G., Hacke, W., Fox, K. A., Lincoff, A. M., Topol, E. J., Berger, P. B., Investigators, Charisma Smoking, clopidogrel, and mortality in patients with established cardiovascular disease Circulation 2009 120:2337-2344 DOI:10.1161/circulationaha.109.866533 PMID:19933933 PMCID:PMC2814172
- Hart, R. G., Bhatt, D. L., Hacke, W., Fox, K. A. A., Hankey, G. J., Berger, P. B., Hu, T. F., Topol, E. J., Invest, Charisma Clopidogrel and aspirin versus aspirin alone for the prevention of stroke in patients with a history of atrial fibrillation: Subgroup analysis of the charisma randomized trial Cerebrovascular Diseases 2008 25:344-347 DOI:10.1159/000118380 PMID:18303254
- Wang, T. H., Bhatt, D. L., Fox, K. A. A., Steinhubl, S. R., Brennan, D. M., Hacke, W., Mak, K. H., Pearson, T. A., Boden, W. E., Steg, P. G., Flather, M. D., Montalescot, G., et al. An analysis of mortality rates with dual-antiplatelet therapy in the primary prevention population of the charisma trial European Heart Journal 2007 28:2200-2207 DOI:10.1093/eurheartj/ehm274 PMID:17673448
- Bhatt, D. L., Flather, M. D., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Hamm, C. W., Hankey, G. J., et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the charisma trial Journal of the American College of Cardiology 2007 49:1982-1988 DOI:10.1016/j.jacc.2007.03.025 PMID:17498584
- Bhatt, D. L., Fox, K. A. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events New England Journal of Medicine 2006 354:1706-1717 DOI:10.1056/NEJMoa060989 PMID:16531616
- Bhatt, D. L., Fox, K. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., et al. A global view of atherothrombosis: baseline characteristics in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial American Heart Journal 2005 150:401.e1-401.e7 DOI:10.1016/j.ahj.2005.03.017 PMID:16169314
- Ringleb, P. A., Bhatt, D. L., Hirsch, A. T., Topol, E. J., Hacke, W., Investigators, Caprie Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events Stroke 2004 35:528-532 DOI:10.1161/01.str.0000110221.54366.49 PMID:14739421
- Wagner, S., Nagel, S., Kluge, B., Schwab, S., Heiland, S., Koziol, J., Gardner, H., Hacke, W. Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia Brain Research 2003 984:63-75 DOI:10.1016/s0006-8993(03)03088-9 PMID:12932840
- Bhatt, D. L., Marso, S. P., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus American Journal of Cardiology 2002 90:625-8 DOI:10.1016/s0002-9149(02)02567-5 PMID:12231089
- Bhatt, D. L., Chew, D. P., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery Circulation 2001 103:363-368 PMID:11157686
- Bhatt, D. L., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J., Investigators, Caprie Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin American Heart Journal 2000 140:67-73 DOI:10.1067/mhj.2000.108239 PMID:10874265
- Van de Werf, F., Adgey, J., Ardissino, D., Armstrong, P. W., Aylward, P., Barbash, G., Betriu, A., Binbrek, A. S., Califf, R., Diaz, R., Fanebust, R., Fox, K., et al. Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: The assent-2 double-blind randomised trial Lancet 1999 354:716-722 DOI:10.1016/s0140-6736(99)07403-6 PMID:10475182
- Koziol, J. A., Hacke, W. A bivariate version of andrews plots IEEE Transactions on Biomedical Engineering 1991 38:1271-1274 DOI:10.1109/10.137294 PMID:1774090
- del Zoppo, G. J., Copeland, B. R., Anderchek, K., Hacke, W., Koziol, J. A. Hemorrhagic transformation following tissue plasminogen-activator in experimental cerebral infarction Stroke 1990 21:596-601 PMID:2109375
- Koziol, J. A., Hacke, W. Multivariate data reduction by principal components, with application to neurological scoring instruments Journal of Neurology 1990 237:461-464 DOI:10.1007/bf00314762 PMID:2074446