recent publications

• academic article

  • Bhatt, D. L., Pare, G., Eikelboom, J. W., Simonsen, K. L., Emison, E. S., Fox, K. A. A., Steg, P. G., Montalescot, G., Bhakta, N., Hacke, W., Flather, M. D., Mak, K. H., et al. The relationship between cyp2c19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: The charisma genetics study European Heart Journal  2012 33:2143-2150  DOI:10.1093/eurheartj/ehs059  PMID:22450429
  • Berger, J. S., Bhatt, D. L., Steg, P. G., Steinhubl, S. R., Montalescot, G., Shao, M. Y., Hacke, W., Fox, K. A., Berger, P. B., Topol, E. J., Lincoff, A. M., Investigators, Charisma Bleeding, mortality, and antiplatelet therapy: Results from the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (charisma) trial American Heart Journal  2011 162:98-105  DOI:10.1016/j.ahj.2011.04.015  PMID:21742095
  • Hankey, G. J., Johnston, S. C., Easton, J. D., Hacke, W., Mas, J. L., Brennan, D., Mak, K. H., Bhatt, D. L., Fox, K. A. A., Topol, E. J., Investigators, Charisma Trial Effect of clopidogrel plus asa vs. Asa early after tia and ischaemic stroke: A substudy of the charisma trial International Journal of Stroke  2011 6:3-9  DOI:10.1111/j.1747-4949.2010.00535.x  PMID:21205234
  • Berger, P. B., Bhatt, D. L., Fuster, V., Steg, P. G., Fox, K. A. A., Shao, M. Y., Brennan, D. M., Hacke, W., Montalescot, G., Steinhubl, S. R., Topol, E. J., Investigators, Charisma Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease Circulation  2010 121:2575-2583  DOI:10.1161/circulationaha.109.895342  PMID:20516378
  • Hankey, G. J., Hacke, W., Easton, J. D., Johnston, S. C., Mas, J. L., Brennan, D. M., Bhatt, D. L., Fox, K. A. A., Topol, E. J., Investigators, Charisma Trial Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients a prespecified substudy of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management and avoidance (charisma) trial Stroke  2010 41:1679-1683  DOI:10.1161/strokeaha.110.586727  PMID:20595658
  • Berger, J. S., Bhatt, D. L., Steinhubl, S. R., Shao, M. Y., Steg, P. G., Montalescot, G., Hacke, W., Fox, K. A., Lincoff, A. M., Topol, E. J., Berger, P. B., Investigators, Charisma Smoking, clopidogrel, and mortality in patients with established cardiovascular disease Circulation  2009 120:2337-2344  DOI:10.1161/circulationaha.109.866533  PMID:19933933  PMCID:PMC2814172
  • Hart, R. G., Bhatt, D. L., Hacke, W., Fox, K. A. A., Hankey, G. J., Berger, P. B., Hu, T. F., Topol, E. J., Invest, Charisma Clopidogrel and aspirin versus aspirin alone for the prevention of stroke in patients with a history of atrial fibrillation: Subgroup analysis of the charisma randomized trial Cerebrovascular Diseases  2008 25:344-347  DOI:10.1159/000118380  PMID:18303254
  • Wang, T. H., Bhatt, D. L., Fox, K. A. A., Steinhubl, S. R., Brennan, D. M., Hacke, W., Mak, K. H., Pearson, T. A., Boden, W. E., Steg, P. G., Flather, M. D., Montalescot, G., et al. An analysis of mortality rates with dual-antiplatelet therapy in the primary prevention population of the charisma trial European Heart Journal  2007 28:2200-2207  DOI:10.1093/eurheartj/ehm274  PMID:17673448
  • Bhatt, D. L., Flather, M. D., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Hamm, C. W., Hankey, G. J., et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the charisma trial Journal of the American College of Cardiology  2007 49:1982-1988  DOI:10.1016/j.jacc.2007.03.025  PMID:17498584
  • Bhatt, D. L., Fox, K. A. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events New England Journal of Medicine  2006 354:1706-1717  DOI:10.1056/NEJMoa060989  PMID:16531616
  • Bhatt, D. L., Fox, K. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., et al. A global view of atherothrombosis: baseline characteristics in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial American Heart Journal  2005 150:401.e1-401.e7  DOI:10.1016/j.ahj.2005.03.017  PMID:16169314
  • Ringleb, P. A., Bhatt, D. L., Hirsch, A. T., Topol, E. J., Hacke, W., Investigators, Caprie Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events Stroke  2004 35:528-532  DOI:10.1161/01.str.0000110221.54366.49  PMID:14739421
  • Wagner, S., Nagel, S., Kluge, B., Schwab, S., Heiland, S., Koziol, J., Gardner, H., Hacke, W. Topographically graded postischemic presence of metalloproteinases is inhibited by hypothermia Brain Research  2003 984:63-75  DOI:10.1016/s0006-8993(03)03088-9  PMID:12932840
  • Bhatt, D. L., Marso, S. P., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus American Journal of Cardiology  2002 90:625-8  DOI:10.1016/s0002-9149(02)02567-5  PMID:12231089
  • Bhatt, D. L., Chew, D. P., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery Circulation  2001 103:363-368  PMID:11157686
  • Bhatt, D. L., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J., Investigators, Caprie Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin American Heart Journal  2000 140:67-73  DOI:10.1067/mhj.2000.108239  PMID:10874265
  • Van de Werf, F., Adgey, J., Ardissino, D., Armstrong, P. W., Aylward, P., Barbash, G., Betriu, A., Binbrek, A. S., Califf, R., Diaz, R., Fanebust, R., Fox, K., et al. Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: The assent-2 double-blind randomised trial Lancet  1999 354:716-722  DOI:10.1016/s0140-6736(99)07403-6  PMID:10475182
  • Koziol, J. A., Hacke, W. A bivariate version of andrews plots IEEE Transactions on Biomedical Engineering  1991 38:1271-1274  DOI:10.1109/10.137294  PMID:1774090
  • del Zoppo, G. J., Copeland, B. R., Anderchek, K., Hacke, W., Koziol, J. A. Hemorrhagic transformation following tissue plasminogen-activator in experimental cerebral infarction Stroke  1990 21:596-601  PMID:2109375
  • Koziol, J. A., Hacke, W. Multivariate data reduction by principal components, with application to neurological scoring instruments Journal of Neurology  1990 237:461-464  DOI:10.1007/bf00314762  PMID:2074446