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Tachykinin regulation of serotonin release: enhancement of [3H]serotonin release from rat cerebral cortex by neuromedin K and substance P acting at distinct receptor sites

Academic Article
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Overview

authors

  • Solti, M.
  • Bartfai, Tamas

publication date

  • 1987

journal

  • Brain Research  Journal

abstract

  • Neuromedin K and substance P (SP) enhanced the basal (5 mM K+) and potassium-evoked (40 mM K+) release of [3H]5-hydroxytryptamine ([3H]5-HT) from slices of the rat cerebral cortex. The effects of the two tachykinins were additive. The SP antagonist span-tide ([D-Arg1, D-Trp7.9, Leu11]-SP) (10(-6) M) inhibited the stimulatory effect of SP but not of neuromedin K on the release of [3H]5-HT. These findings suggest that the two tachykinins exhibit their effects on serotonin release at distinct receptor sites.

subject areas

  • Animals
  • Cerebral Cortex
  • Drug Synergism
  • Male
  • Neurokinin B
  • Neuropeptides
  • Potassium
  • Rats
  • Rats, Inbred Strains
  • Serotonin
  • Substance P
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(87)91424-7

PubMed ID

  • 2434195
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Additional Document Info

start page

  • 377

end page

  • 380

volume

  • 401

issue

  • 2

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