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Subchronic glucocorticoid pretreatment reversibly attenuates IL-1 beta induced fever in rats; IL-6 mRNA is elevated while IL-1 alpha and IL-1 beta mRNAs are suppressed, in the CNS

Academic Article
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Overview

authors

  • Chai, Z.
  • Alheim, K.
  • Lundkvist, J.
  • Gatti, S.
  • Bartfai, Tamas

publication date

  • 1996

journal

  • Cytokine  Journal

abstract

  • Subchronic (36 h) exposure of rats to corticosterone (CS) (100 mg/pellet,subcutaneously), blocked the pyrogenic response to recombinant human interleukin 113 (rhIL-1 beta, 5 mu g/kg, ip.). CS treatment reduced the basal mRNA levels of IL-1 alpha and IL-1 beta, but elevated the mRNA levels of IL-6 in the hypothalamus and hippocampus as shown by RT-PCR. The CS treatment clamped the cytokine mRNA levels, and injection of rhIL-1 beta to CS treated rats did not significantly affect these altered mRNA levels. IL-6 bioactivity in serum was not significantly changed by CS treatment, but increased 50 times upon injection of rhIL-1 beta. rhIL-1 beta caused a significantly lower induction of serum IL-6 levels in CS pretreated rats (9-fold). The pyrogenic response to injection of rhIL-1 beta has returned 5 days after the removal of the corticosterone pellet, and the hypothalamic cytokine mRNA levels (IL-1 alpha, IL-1 beta and IL-6) have returned to basal. These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible.

subject areas

  • Analysis of Variance
  • Animals
  • Antigens, CD
  • Body Temperature
  • Corticosterone
  • DNA Primers
  • Drug Implants
  • Fever
  • Glucocorticoids
  • Hippocampus
  • Humans
  • Hypothalamus
  • Interleukin-1
  • Interleukin-6
  • Kinetics
  • Male
  • Polymerase Chain Reaction
  • Pyrogens
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Interleukin
  • Receptors, Interleukin-6
  • Recombinant Proteins
  • Time Factors
  • Transcription, Genetic
  • Tumor Necrosis Factor-alpha
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Research

keywords

  • fever
  • glucocorticoids
  • interleukin 1
  • interleukin 6
  • tumour necrosis factor alpha
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Identity

International Standard Serial Number (ISSN)

  • 1043-4666

Digital Object Identifier (DOI)

  • 10.1006/cyto.1996.0032

PubMed ID

  • 8833038
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Additional Document Info

start page

  • 227

end page

  • 237

volume

  • 8

issue

  • 3

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