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EEG effects of RO-15-4513 and FG-7142 alone and in combination with ethanol

Academic Article
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Overview

authors

  • Ehlers, Cindy
  • Chaplin, R. I.
  • Koob, George

publication date

  • July 1990

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • The electrophysiological effects of Ro 15-4513 and FG 7142 alone and in combination with ethanol were investigated. Intraperitoneal administration of Ro 15-4513 (3, 6 mg/kg) was found to significantly increase power in the 6-16 Hz frequency range, an effect which was antagonized by ethanol (1 g/kg). FG 7142 administration (2, 5 mg/kg IP) was found to enhance spectral power in the 6-8 Hz range, an effect which was also blocked by coadministration of ethanol. Both drugs also produced dose-related abnormal EEG activity in the form of episodic bursts of EEG spiking. These ictal episodes, which lasted 5-40 seconds, were associated with an arrest of behavior but no overt behavioral convulsions. Coadministration of ethanol caused an elimination or significant reduction in these episodes. These studies suggest that Ro 15-4513 and FG 7142 have potent electrophysiological actions of their own which are partially antagonized by ethanol.

subject areas

  • Animals
  • Azides
  • Benzodiazepines
  • Carbolines
  • Cerebral Cortex
  • Drug Interactions
  • Electroencephalography
  • Ethanol
  • Hippocampus
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(90)90263-h

PubMed ID

  • 2165619
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Additional Document Info

start page

  • 607

end page

  • 611

volume

  • 36

issue

  • 3

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