recent publications

• academic article

  • Culyba, E. K., Price, J. L., Hanson, S. R., Dhar, A., Wong, C. H., Gruebele, M., Powers, E. T., Kelly, J. W. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns Science  2011 331:571-575  DOI:10.1126/science.1198461  PMID:21292975  PMCID:PMC3099596
  • Price, J. L., Shental-Bechor, D., Dhar, A., Turner, M. J., Powers, E. T., Gruebele, M., Levy, Y., Kelly, J. W. Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics Journal of the American Chemical Society  2010 132:15359-15367  DOI:10.1021/ja106896t  PMID:20936810  PMCID:PMC2965790
  • Fuller, A. A., Du, D., Liu, F., Davoren, J. E., Bhabha, G., Kroon, G., Case, D. A., Dyson, H. J., Powers, E. T., Wipf, P., Gruebele, M., Kelly, J. W. Evaluating beta-turn mimics as beta-sheet folding nucleators Proceedings of the National Academy of Sciences of the United States of America  2009 106:11067-11072  DOI:10.1073/pnas.0813012106  PMID:19541614  PMCID:PMC2708776
  • Liu, F., Du, D. G., Fuller, A. A., Davoren, J. E., Wipf, P., Kelly, J. W., Gruebele, M. An experimental survey of the transition between two-state and downhill protein folding scenarios Proceedings of the National Academy of Sciences of the United States of America  2008 105:2369-2374  DOI:10.1073/pnas.0711908105  PMID:18268349  PMCID:PMC2268143
  • Jager, M., Deechongkit, S., Koepf, E. K., Nguyen, H., Gao, J. M., Powers, E. T., Gruebele, M., Kelly, J. W. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective Biopolymers  2008 90:751-758  DOI:10.1002/bip.21101  PMID:18844292
  • Jaeger, M., Nguyen, H., Dendle, M., Gruebele, M., Kelly, J. W. Influence of hPin1 WWN-terminal domain boundaries on function, protein stability, and folding Protein Science  2007 16:1495-1501  DOI:10.1110/ps.072775507  PMID:17586778  PMCID:PMC2206688
  • Deechongkit, S., Nguyen, H., Jager, M., Powers, E. T., Gruebele, M., Kelly, J. W. Beta-sheet folding mechanisms from perturbation energetics Current Opinion in Structural Biology  2006 16:94-101  DOI:10.1016/j.sbi.2006.01.014  PMID:16442278
  • Jager, M., Zhang, Y., Bieschke, J., Nguyen, H., Dendle, M., Bowman, M. E., Noel, J. P., Gruebele, M., Kelly, J. W. Structure-function-folding relationship in a WW domain Proceedings of the National Academy of Sciences of the United States of America  2006 103:10648-10653  DOI:10.1073/pnas.0600511103  PMID:16807295  PMCID:PMC1502286
  • Nguyen, H., Jager, M., Kelly, J. W., Gruebele, M. Engineering a beta-sheet protein toward the folding speed limit Journal of Physical Chemistry B  2005 109:15182-15186  DOI:10.1021/jp052373y  PMID:16852923
  • Deechongkit, S., Nguyen, H., Powers, E. T., Dawson, P. E., Gruebele, M., Kelly, J. W. Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics Nature  2004 430:101-105  DOI:10.1038/nature02611  PMID:15229605
  • Nguyen, H., Jager, M., Moretto, A., Gruebele, M., Kelly, J. W. Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation Proceedings of the National Academy of Sciences of the United States of America  2003 100:3948-3953  DOI:10.1073/pnas.0538054100  PMID:12651955  PMCID:PMC153028
  • Jager, M., Nguyen, H., Crane, J. C., Kelly, J. W., Gruebele, M. The folding mechanism of a beta-sheet: the WW domain Journal of Molecular Biology  2001 311:373-393  DOI:10.1006/jmbi.2001.4873  PMID:11478867
  • Crane, J. C., Koepf, E. K., Kelly, J. W., Gruebele, M. Mapping the transition state of the WW domain beta-sheet Journal of Molecular Biology  2000 298:283-292  DOI:10.1006/jmbi.2000.3665  PMID:10764597