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Activation of big map kinase 1 (bmk1/erk5) inhibits cardiac injury after myocardial ischernia and reperfusion

Academic Article
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Overview

authors

  • Cameron, S. J.
  • Itoh, S.
  • Baines, C. P.
  • Zhang, C. X.
  • Ohta, S.
  • Che, W. Y.
  • Glassman, M.
  • Lee, Jiing-Dwan
  • Yan, C.
  • Yang, J.
  • Abe, J.

publication date

  • May 2004

journal

  • FEBS Letters  Journal

abstract

  • Big MAP kinase 1 (BMK1/ERK5) plays a critical role in pre-natal development of the cardiovascular system and post-natal eccentric hypertrophy of the heart. Of the two isoforms upstream of MAPK-kinase 5 (MEK5) known to exist, only the longer MEK5alpha isoform potently activates BMK1. We generated cardiac-specific constitutively active form of the MEK5alpha (CA-MEK5alpha transgenic (Tg) mice), and observed a 3 to 4-fold increase in endogenous BMK1 activation and hyperphosphorylation of connexin 43 in the ventricles of the Tg compared to wild-type mice. The CA-MEK5alpha-Tg-mice demonstrated a profoundly accelerated recovery of left ventricular developed pressure after ischemia/reperfusion. We propose a novel role for BMK1 in protecting the heart from ischemia/reperfusion-induced cardiac injury.

subject areas

  • Animals
  • Caspases
  • Connexin 43
  • Echocardiography
  • Enzyme Activation
  • Gene Expression
  • Heart
  • Isoenzymes
  • Mice
  • Mice, Transgenic
  • Mitogen-Activated Protein Kinase 7
  • Mitogen-Activated Protein Kinases
  • Myocardial Ischemia
  • Myocardial Reperfusion Injury
  • Phosphorylation
  • Ventricular Function
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Research

keywords

  • MAP kinase
  • MAPK-kinase 5
  • big MAP kinase 1
  • cardiac physiology
  • hypoxia/reperfusion-injury
  • transgenic
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Identity

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2004.03.120

PubMed ID

  • 15147905
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Additional Document Info

start page

  • 255

end page

  • 260

volume

  • 566

issue

  • 1-3

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