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Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase

Academic Article
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Overview

authors

  • Du, W.
  • Hardouin, C.
  • Cheng, H.
  • Hwang, I.
  • Boger, Dale

publication date

  • January 2005

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.

subject areas

  • Amidohydrolases
  • Enzyme Inhibitors
  • Heterocyclic Compounds
  • Sulfones
  • Sulfoxides
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2004.10.025

PubMed ID

  • 15582420
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Additional Document Info

start page

  • 103

end page

  • 106

volume

  • 15

issue

  • 1

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