recent publications

• academic article

  • Trewhella, J., Hendrickson, W. A., Kleywegt, G. J., Sali, A., Sato, M., Schwede, T., Svergun, D. I., Tainer, J. A., Westbrook, J., Berman, H. M. Report of the wwPDB Small-Angle Scattering Task Force: data requirements for biomolecular modeling and the PDB Structure  2013 21:875-881  DOI:10.1016/j.str.2013.04.020  PMID:23747111
  • Xie, H., Ng, D., Savinov, S. N., Dey, B., Kwong, P. D., Wyatt, R., Smith, A. B., Hendrickson, W. A. Structure-activity relationships in the binding of chemically derivatized cd4 to gp120 from human immunodeficiency virus Journal of Medicinal Chemistry  2007 50:4898-4908  DOI:10.1021/jm070564e  PMID:17803292  PMCID:PMC2532594
  • Huang, C. C., Stricher, F., Martin, L., Decker, J. M., Majeed, S., Barthe, P., Hendrickson, W. A., Robinson, J., Roumestand, C., Sodroski, J., Wyatt, R., Shaw, G. M., et al. Scorpion-toxin mimics of cd4 in complex with human immunodeficiency virus gp120: Crystal structures, molecular mimicry, and neutralization breadth Structure  2005 13:755-768  DOI:10.1016/j.str.2005.03.006  PMID:15893666
  • Huang, C. C., Venturi, M., Majeed, S., Moore, M. J., Phogat, S., Zhang, M. Y., Dimitrov, D. S., Hendrickson, W. A., Robinson, J., Sodroski, J., Wyatt, R., Choe, H., et al. Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120 Proceedings of the National Academy of Sciences of the United States of America  2004 101:2706-2711  DOI:10.1073/pnas.0308527100  PMID:14981267  PMCID:PMC365685
  • Koch, M., Pancera, M., Kwong, P. D., Kolchinsky, P., Grundner, C., Wang, L. P., Hendrickson, W. A., Sodroski, J., Wyatt, R. Structure-based, targeted deglycosylation of hiv-1 gp120 and effects on neutralization sensitivity and antibody recognition Virology  2003 313:387-400  DOI:10.1016/s0042-6822(03)00294-0  PMID:12954207
  • Kwong, P. D., Doyle, M. L., Casper, D. J., Cicala, C., Leavitt, S. A., Majeed, S., Steenbeke, T. D., Venturi, M., Chaiken, I., Fung, M., Katinger, H., Parren, Pwlh, et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites Nature  2002 420:678-682  DOI:10.1038/nature01188  PMID:12478295
  • Xiang, S. H., Kwong, P. D., Gupta, R., Rizzuto, C. D., Casper, D. J., Wyatt, R., Wang, L. P., Hendrickson, W. A., Doyle, M. L., Sodroski, J. Mutagenic stabilization and/or disruption of a cd4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein Journal of Virology  2002 76:9888-9899  DOI:10.1128/jvi.76.19.9888-9899.2002  PMID:12208966
  • Kwong, P. D., Wyatt, R., Majeed, S., Robinson, J., Sweet, R. W., Sodroski, J., Hendrickson, W. A. Structures of hiv-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates Structure  2000 8:1329-1339  DOI:10.1016/s0969-2126(00)00547-5  PMID:11188697
  • Myszka, D. G., Sweet, R. W., Hensley, P., Brigham-Burke, M., Kwong, P. D., Hendrickson, W. A., Wyatt, R., Sodroski, J., Doyle, M. L. Energetics of the hiv gp120-cd4 binding reaction Proceedings of the National Academy of Sciences of the United States of America  2000 97:9026-9031  DOI:10.1073/pnas.97.16.9026  PMID:10922058
  • Kwong, P. D., Wyatt, R., Sattentau, Q. J., Sodroski, J., Hendrickson, W. A. Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus Journal of Virology  2000 74:1961-1972  DOI:10.1128/jvi.74.4.1961-1972.2000  PMID:10644369
  • Kwong, P. D., Wyatt, R., Desjardins, E., Robinson, J., Culp, J. S., Hellmig, B. D., Sweet, R. W., Sodroski, J., Hendrickson, W. A. Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (hiv-1) Journal of Biological Chemistry  1999 274:4115-4123  DOI:10.1074/jbc.274.7.4115  PMID:9933605
  • Rizzuto, C. D., Wyatt, R., Hernandez-Ramos, N., Sun, Y., Kwong, P. D., Hendrickson, W. A., Sodroski, J. A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding Science  1998 280:1949-1953  DOI:10.1126/science.280.5371.1949  PMID:9632396
  • Kwong, P. D., Wyatt, R., Robinson, J., Sweet, R. W., Sodroski, J., Hendrickson, W. A. Structure of an hiv gp120 envelope glycoprotein in complex with the cd4 receptor and a neutralizing human antibody Nature  1998 393:648-659  PMID:9641677
  • Tainer, J. A., Getzoff, E. D., Alexander, H., Houghten, R. A., Olson, A. J., Lerner, R. A., Hendrickson, W. A. The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein Nature  1984 312:127-134  DOI:10.1038/312127a0  PMID:6209578
  • Alden, R. A., Bricogne, G., Freer, S. T., Hall, S. R., Hendrickson, W. A., Machin, P. A., Munn, R. J., Olson, A. J., Reeke, G. N., Sheriff, S., Stewart, J. M., Sygusch, J., et al. Cooperative programming in crystallography Computers and Chemistry  1983 7:137-148  DOI:10.1016/0097-8485(83)85005-0