recent publications

• academic article

  • Deshpande, R. A., Williams, G. J., Limbo, O., Williams, R. S., Kuhnlein, J., Lee, J. H., Classen, S., Guenther, G., Russell, P., Tainer, J. A., Paull, T. T. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling EMBO Journal  2014 33:482-500  DOI:10.1002/embj.201386100  PMID:24493214  PMCID:PMC3989629
  • Williams, G. J., Williams, R. S., Williams, J. S., Moncalian, G., Arvai, A. S., Limbo, O., Guenther, G., SilDas, S., Hammel, M., Russell, P., Tainer, J. A. ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair Nature Structural & Molecular Biology  2011 18:423-431  DOI:10.1038/nsmb.2038  PMID:21441914  PMCID:PMC3118400
  • Prudden, J., Perry, J. J. P., Nie, M. H., Vashisht, A. A., Arvai, A. S., Hitomi, C., Guenther, G., Wohlschlegel, J. A., Tainer, J. A., Boddy, M. N. DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes Molecular and Cellular Biology  2011 31:2299-2310  DOI:10.1128/mcb.05188-11  PMID:21444718  PMCID:PMC3133251
  • Tsutakawa, S. E., Classen, S., Chapados, B. R., Arvai, A. S., Finger, L. D., Guenther, G., Tomlinson, C. G., Thompson, P., Sarker, A. H., Shen, B. H., Cooper, P. K., Grasby, J. A., et al. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the fen1 superfamily Cell  2011 145:198-211  DOI:10.1016/j.cell.2011.03.004  PMID:21496641  PMCID:PMC3086263
  • Williams, J. S., Williams, R. S., Dovey, C. L., Guenther, G., Tainer, J. A., Russell, P. gamma H2A binds Brc1 to maintain genome integrity during S-phase EMBO Journal  2010 29:1136-1148  DOI:10.1038/emboj.2009.413  PMID:20094029  PMCID:PMC2845269
  • Williams, R. S., Dodson, G. E., Limbo, O., Yamada, Y., Williams, J. S., Guenther, G., Classen, S., Glover, J. N. M., Iwasaki, H., Russell, P., Tainer, J. A. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair Cell  2009 139:87-99  DOI:10.1016/j.cell.2009.07.033  PMID:19804755  PMCID:PMC2762657
  • Williams, R. S., Moncalian, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L. M., Cahill, D., Hitomi, C., Guenther, G., Moiani, D., Carney, J. P., et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair Cell  2008 135:97-109  DOI:10.1016/j.cell.2008.08.017  PMID:18854158  PMCID:PMC2681233