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Natural sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells

Academic Article
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Overview

related to degree

  • Wu, Douglass, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Kinjo, Y.
  • Pei, B.
  • Bufali, S.
  • Raju, R.
  • Richardson, S. K.
  • Imamura, M.
  • Fujio, M.
  • Wu, Douglass
  • Khurana, A.
  • Kawahara, K.
  • Wong, Chi-Huey
  • Howell, A. R.
  • Seeberger, P. H.
  • Kronenberg, M.

publication date

  • July 2008

journal

  • Chemistry & Biology  Journal

abstract

  • Mouse natural killer T (NKT) cells expressing an invariant T cell antigen receptor (TCR) recognize glycosphingolipids (GSLs) from Sphingomonas bacteria. The synthetic antigens previously tested, however, were designed to closely resemble the potent synthetic agonist alpha-galactosyl ceramide (alphaGalCer), which contains a monosaccharide and a C18:0 sphingosine lipid. Some Sphingomonas bacteria, however, also have oligosaccharide-containing GSLs, and they normally synthesize several GSLs with different sphingosine chains including one with a cyclopropyl ring-containing C21:0 (C21cycl) sphingosine. Here we studied the stimulation of NKT cells with synthetic GSL antigens containing natural tetrasaccharide sugars, or the C21cycl sphingosine. Our results indicate that there is a great degree of variability in the antigenic potency of different natural Sphingomonas glycolipids, with the C21cycl sphingosine having intermediate potency and the oligosaccharide-containing antigens exhibiting limited or no stimulatory capacity.

subject areas

  • Animals
  • Antigens
  • Cell Line
  • Cytokines
  • Glycolipids
  • Hybridomas
  • Killer Cells, Natural
  • Lipids
  • Lymphocytes
  • Mice
  • Mice, Inbred C57BL
  • Models, Biological
  • Models, Chemical
  • Oligosaccharides
  • Sphingomonas
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Identity

PubMed Central ID

  • PMC2519143

International Standard Serial Number (ISSN)

  • 1074-5521

Digital Object Identifier (DOI)

  • 10.1016/j.chembiol.2008.05.012

PubMed ID

  • 18635002
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Additional Document Info

start page

  • 654

end page

  • 664

volume

  • 15

issue

  • 7

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